Posted 3/25/2024
Scientists and clinicians whose discoveries have shaped the understanding of HIV disease will provide updates on the...
Posted 2/22/2024
There are many paths for women to travel to find success in science. That was a crucial theme conveyed by the four...
Posted 2/7/2024
Frederick National Laboratory researchers identified a vitamin A derivative (retinoid) that when combined with a...
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Building an interdisciplinary pain medicine and palliative care program in Ethiopia
Posted 4/12/2020
Cancer is beginning to eclipse infectious disease as a major cause of mortality in low-to-middle income countries like those in sub-Saharan Africa. In Ethiopia, people with cancer who reach a hospital are diagnosed with advanced disease for which there is little treatment available and practically nothing to stem their unbearable disease-related pain. The Ethiopian…
Building an interdisciplinary pain medicine and palliative care program in Ethiopia
Posted 4/12/2020Cancer is beginning to eclipse infectious disease as a major cause of mortality in low-to-middle income countries like those in sub-Saharan Africa. In Ethiopia, people with cancer who reach a hospital are diagnosed with advanced disease for which there is little treatment available and practically nothing to stem their unbearable disease-related pain. The Ethiopian government…
Trans-NIH Study Shows HPV Vaccine Benefits Women Following Donor Stem Cell Transplant
Posted 2/27/2020Immune Response Induced by Vaccination May Lower Risk of New HPV Infections and Associated HPV-Related Cancers in Post-Transplant Women
Women who completed a three-dose series of the HPV vaccine following a donor stem cell transplant developed a surprisingly robust immune response to vaccination, which was not significantly different from the responses in healthy women.…
Frederick National Laboratory's Biopharma Development Program Set to Manufacture CAR-T Cell Therapy
Biopharmaceutical Development ProgramPosted 2/18/2020A team from the Frederick National Laboratory’s Biopharmaceutical Development Program is developing a new autologous cell therapy line that uses engineered chimeric antigen receptor (CAR) T cells to treat acute myeloid leukemia, a particularly aggressive form of pediatric blood cancer. This foray into cell immunotherapy represents a new avenue of research and development for…
Technological Marvels Ready Natural Products for Drug Discovery
Posted 2/5/2020Jason Evans is giving me a tour of the new NCI Program for Natural Products Discovery (NPNPD) facility when he pauses to look at a sample-handling robot under repair, its mechanical insides temporarily disemboweled. I ask if he has an electrical engineering background, and he laughs. Evans is a scientific programmer, but for him and his colleagues, that’s beside the point…
FNL HIV Investigator Brandon Keele Shapes Peer Research with Multiple Seminal and Highly Cited Papers
Retroviral Evolution Section, AIDS and Cancer Virus Program, Brandon KeelePosted 2/2/2020
Discoveries by AIDS researcher Brandon F. Keele, Ph.D. have not only put him on the leading edge of research to prevent and treat HIV infection. He’s also influenced the work of his peers.
Keele, a senior principal scientist and the principal investigator of the Retroviral Evolution Section in the AIDS and Cancer Virus Program at the Frederick National Laboratory was…
National Lab Team Harnesses Metabolism for Therapy in Pancreatic Cancer
Posted 1/27/2020A team led by Frank McCormick, Ph.D., FRS, D.Sc. (Hon), RAS National Program Advisor at the Frederick National Laboratory for Cancer Research and professor emeritus at UCSF Helen Diller Family Comprehensive Cancer Center, has found a new vulnerability in pancreatic cancer and revealed a potential strategy for combating one of the most treatment-resistant malignancies.
The…
RAS Initiative has replaced mystery with momentum
Posted 1/17/2020It started as an ambitious shot in the dark, a plunge into the scientific unknown. But the National Cancer Institute RAS Initiative has quickly helped to reverse the field’s perspective on a problem long considered unsolvable.
When the RAS Initiative was founded in 2013, researchers studying mutated RAS proteins (cancer-causing variants of the three common RAS molecules in…
Cell Division Rates and Cancer Risk Decelerate in Very Old People, but Not in Very Old Mice
Posted 1/13/2020While advancing age is the most important risk factor for cancer, the incidence of the disease decreases in very elderly people.
A study led by Johns Hopkins University provided a potential explanation for this puzzling drop in new cancer diagnoses among the oldest and most rapidly growing segment of western population: that cell division rates – and thus mutations that…
Survivor Brings Drive and Rare Personal Perspective to Ebola Virus Disease Reasearch
Posted 1/8/2020Dr. Ian Crozier Draws on His Own Experience to Inform Studies in Humans and in the Lab
Surviving very severe Ebola virus disease made it clear to Ian Crozier, M.D., that there was a gap to bridge between clinicians caring for patients at outbreak bedsides and the bench scientists peering into fundamental mechanisms of disease to develop prevention and treatment strategies…
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