Brandon Keele in lab

Discoveries by AIDS researcher Brandon F. Keele, Ph.D. have not only put him on the leading edge of research to prevent and treat HIV infection. He’s also influenced the work of his peers.

Keele, a principal investigator and senior principal scientist in the AIDS and Cancer Virus Program at the Frederick National Laboratory was named a Highly Cited Researcher by Web of Science, a global citation database. Keele and colleague Jeffrey Lifson, M.D. were recognized for producing papers that ranked in the top 1 percent by citations for their field.

Artist’s conceptual depiction of a pancreatic cancer cell’s mitochondria interacting with glutamine when enhanced glutamine metabolism contributes to cancer’s progression.

A team led by Frank McCormick, Ph.D., FRS, D.Sc. (Hon), RAS National Program Advisor at the Frederick National Laboratory for Cancer Research and professor emeritus at UCSF Helen Diller Family Comprehensive Cancer Center, has found a new vulnerability in pancreatic cancer and revealed a potential strategy for combating one of the most treatment-resistant malignancies.

RAS Initiative Has Replaced Mystery with Momentum Speaker

It started as an ambitious shot in the dark, a plunge into the scientific unknown. But the National Cancer Institute RAS Initiative has quickly helped to reverse the field’s perspective on a problem long considered unsolvable.

Baktiar Karim in the Molecular Histopathology Laboratory at the Frederick National Laboratory for Cancer Research.

While advancing age is the most important risk factor for cancer, the incidence of the disease decreases in very elderly people.

 Dr. Ian Crozier (right) and colleague Dr. Ali Dilu from the Institut National pour la Rechere Biomedicale en route by helicopter to Komanda in the DRC  to deliver urgent investigational product and training to the Komanda Ebola Treatment Center in February 2019.

Dr. Ian Crozier Draws on His Own Experience to Inform Studies in Humans and in the Lab

Surviving very severe Ebola virus disease made it clear to Ian Crozier, M.D., that there was a gap to bridge between clinicians caring for patients at outbreak bedsides and the bench scientists peering into fundamental mechanisms of disease to develop prevention and treatment strategies.

Frederick National Laboratory Part of SC19 “Best Paper” Team

A multidisciplinary team including members of the Frederick National Laboratory has been recognized with the “Best Paper” award at SC19, a prestigious international conference for high-performance computing, networking, storage, and analysis. Of the 344 papers submitted to SC19, only 87 were accepted, and just one was named Best Paper.

Families go to the Ebola Treatment Center to visit a family member who is held in quarantine. [Credit: World Bank/Vincent Tremeau, republished here under CC BY-NC-ND 2.0]

FREDERICK, Md. -- “Sure, it’s easier than doing research in more isolated places, say Antarctica, or outer space—but that does not make it easy for those on the ground. Sometimes densely populated areas pose problems of their own. Not everyone agrees on the need, the presence of so many ‘outsiders,’ or on the approach taken. People were attacked. Research sites were burned.”

Molecular Cancer Therapeutics journal cover featuring the FNL study.

FREDERICK, Md. -- High levels of the enzyme tyrosine threonine kinase (TTK) in many types of cancer cells, including lung cancer, contribute to uncontrolled cell growth. A study published by Frederick National Laboratory Director Ethan Dmitrovsky, M.D. and his laboratory team demonstrated that a promising anti-TTK treatment that acts against many of those types of cancer cells also results in lung cancer cell death. 

Image of original whole-slide image of liver tumor with annotation by pathologists, courtesy PAIP 2019.

FREDERICK, Md. – Frederick National Laboratory for Cancer Research’s medical imaging expertise received the highest rating at a recent grand challenge for pathology that featured nearly 1,000 competitors from around the world.

Tanja Grkovic inspects a 384 well plate containing natural product chemical fractions before it is shipped out for screening.

FREDERICK, Md. -- Tree bark, microbes, and mold are not simply the stuff you rake in the back yard and track in on the bottom of your shoes. They just might be a treatment for a rare disease. 

Products found in nature gave rise to some of our most familiar and relied-upon therapies including some antibiotics and decongestants and aspirin. There may be another treatment contained in a sea sponge or a leaf, but sifting through to isolate that compound is a complex undertaking. Scientists find natural products notoriously difficult to work with.

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