An analysis of data from two clinical trials in sub-Saharan Africa, a region with one of the highest cervical cancer...
Many cancer cells–and lung cancers in particular–have an abnormal number of chromosomes, a feature that can help shield...
Scientists and clinicians whose discoveries have shaped the understanding of HIV disease will provide updates on the...

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'Empanada' is a leap forward in rapid 3-D image processing and annotation

Cancer Research Technology ProgramPosted 7/10/2024
It sounds like a pastry but it’s really part of a new wave in scientific imaging. Empanada is the name of an artificial intelligence (AI) program trained on a vast set of data for more rapid and accurate 3-D rendering of subcellular structures. Interested investigators can download it for free. “At the snap of a finger, you can identify all of the mitochondria in a…

Newly identified antibodies block many influenza strains in laboratory tests

Cancer Research Technology ProgramPosted 7/8/2024
Seeking a universal flu vaccine, scientists have identified two antibodies that block a wide range of influenza viruses by targeting a region of the viral structure that was discovered 40 years ago but has yet to be successfully exploited.   Flu vaccines typically target hemagglutinin, the most abundant and accessible protein on the surface of the virus. But the head…

Microscopy mini-course teaches critical but often missing skills

Cancer Research Technology ProgramPosted 7/1/2024
Ru-ching Hsia, Ph.D., heard the same concern from colleagues across the country: There is a dearth of electron microscopy training opportunities in the United States, and it’s limiting biological sciences. Hsia, who heads the Electron Microscopy Laboratory at the Frederick National Laboratory (FNL), realized that FNL could help fill this need and train the next…

Biotech Connector explores the high-resolution world of electron microscopy

Biotech Connector, Partnership Development OfficePosted 6/27/2024
The spring Biotech Connector, a quarterly networking and speaker series, on May 23 gave an overview of the electron microscope and its uses—from the first electron microscopy (EM) image of an intact cell published in 1944 to an array of modern techniques that are changing our understanding of cell biology. The event featured two speakers from the Frederick National Laboratory…

Scientists say effective control of COVID-19 depends on universal use of serological standards

Vaccine, Immunity, and Cancer Directorate, HPV and COVID-19 Serology Laboratories, Ligia Pinto, Human SARS-CoV-2 Serology Standard, HPV Serology Operating ProceduresPosted 5/29/2024
Despite the growing volume of data from results of hundreds of COVID-19 serology test kits, experts say the differences among testing platforms mean the data is difficult to compare, limiting the potential to leverage existing data to guide public health decisions. The World Health Organization’ International Standard for SARS-CoV-2 is a tool that can help researchers…

Comparative analysis adds evidence in favor of one-dose HPV vaccination in girls

Vaccine, Immunity, and Cancer Directorate, HPV and COVID-19 Serology Laboratories, Ligia PintoPosted 5/21/2024
An analysis of data from two clinical trials in sub-Saharan Africa, a region with one of the highest cervical cancer rates worldwide, suggests that just one dose of a human papillomavirus vaccine is enough to protect girls from HPV infection for up to two years. These data support previous evidence showing the efficacy of a single dose and the recent World Health…

FNL joins two panels at 2024 BIO International Convention

Center for Innovation and Strategic Partnerships, Partnership Development Office, Vladimir Popov, Maggie ScullyPosted 5/14/2024
Partnership development leaders at the Frederick National Laboratory for Cancer Research (FNL) will share their perspectives on how personalized medicine is changing drug development and how to tap into resources at federal laboratories as part of two upcoming panel sessions at the 2024 BIO International Convention, June 3–6 in San Diego. BIO is the world’s largest…

New CRISPR screening platform could drive development of next-generation drugs

Genome Modification Core, Laboratory Animal Sciences ProgramPosted 5/2/2024
Scientists at the Frederick National Laboratory for Cancer Research (FNL) and their National Cancer Institute colleagues have developed a method that enhances the capacity to identify interactions between proteins and molecules that are critical to drug targeting. The study reported in Science Advances includes libraries to aid other researchers. A bedrock of drug…

RAS Initiative study shines the spotlight on less-understood KRAS4a

Cancer Research Technology Program, Protein Expression Laboratory, RAS InitiativePosted 4/30/2024
A four-year effort undertaken by the NCI RAS Initiative has come to fruition, revealing a host of new information about a less-studied KRAS variant that plays a key role in cell biology and human cancers. The team, comprising specialists within the RAS Initiative’s hub—Frederick National Laboratory’s Cancer Research Technology Program (CRTP)—performed extensive…

Clinical Monitoring Research Program to support clinical study exploring alternative to cervical cancer screening

Clinical Monitoring Research ProgramPosted 4/24/2024
A new U.S. clinical trial will evaluate whether an at-home, self-collection technique to screen for cervical cancer is as accurate and effective as a Pap smear test done in a healthcare clinic. The Clinical Monitoring Research Program Directorate (CMRPD) at the Frederick National Laboratory for Cancer Research will coordinate the National Cancer Institute (NCI) study to be…