A nanoparticle-based flu vaccine discovered and developed by the Vaccine Research Center, National Institute of Allergy...
An initiative at Frederick National Laboratory for Cancer Research (FNL) is confronting what’s been dubbed the...
The classical RAS family of proteins functions as molecular switches at the cell’s plasma membrane where it cycles...

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COVID-19 vaccines bring nanomedicine back into the spotlight

Nanotechnology Characterization LaboratoryPosted 6/15/2022
The success of today’s COVID-19 vaccines has given medical nanotechnology a long-awaited boost, with a renewed interest in its potential for treating disease among big pharma and small start-ups. Over the years, nanotechnology has had its ups and downs in the public eye, cycling from peaks of excitement and fanfare–and a little too much hype–to falling out of favor because…

Nanotechnology experts share insights as they see similarities in hypersensitivity reactions to nanomedicine and mRNA vaccines

Nanotechnology Characterization LaboratoryPosted 5/18/2022
When nanoparticle-based mRNA COVID-19 vaccines were made available in December 2020 and the media began to report the incidence of rare but troubling anaphylaxis, nanomedicine experts including Frederick National Laboratory’s Marina Dobrovolskaia recognized those hypersensitivity reactions. “Everything they reported symptomatically sounded so familiar to us from our work…

Computing collaboration makes massive microscopy analyses possible

Posted 5/11/2022
On any given day, microscopist Susan Lea, D.Phil., and her team at NCI at Frederick collect more data than can fit on any standard hard drive, creating a challenge for data storage and analysis. Their average data collection is 5 terabytes, a quantity roughly 20 times the storage capacity of a 256-gigabyte laptop or the equivalent of storing about 1,250 movies. The…

Nanoparticle-based flu vaccine performs well in early phase clinical trial

Vaccine Clinical Materials ProgramPosted 5/5/2022
A nanoparticle-based flu vaccine discovered and developed by the Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), was manufactured by Frederick National Laboratory (FNL) for a Vaccine Research Center Phase 1 clinical trial. The vaccine was found to be safe, well-tolerated, and immunogenic against multiple flu subtypes and, with further…

Scientists to present multidisciplinary studies at AACR Annual Meeting

Partnership Development Office, Molecular Characterization Laboratory, Meet us at AACRPosted 4/6/2022
Investigators from the Frederick National Laboratory for Cancer Research will share their latest work regarding the use of pre-clinical models for compound screening and tumor characterization, bioinformatics and technology initiatives, among other topics, at the American Association for Cancer Research 2022 Annual Meeting. More than 30 abstracts by Frederick…

STAR TREC takes on reproducibility, standardization, and better science

STAR TREC, Partnership Development Office, Leonard Freedman, Ph.D.Posted 4/4/2022
An initiative at Frederick National Laboratory for Cancer Research (FNL) is confronting what’s been dubbed the scientific “reproducibility crisis.” The effort, called STAR TREC (the Standards References and Training Research Committee), seeks to help the scientific community address reproducibility issues and aims to spur dialogue about better standards in science.…

New study finds classical RAS proteins are not essential for RAF inhibitor-induced paradoxical ERK activation

RAS InitiativePosted 4/1/2022
The classical RAS family of proteins functions as molecular switches at the cell’s plasma membrane where it cycles between an active and inactive state. The active state initiates a cascade of events that promote downstream signaling to regulate cellular functions, such as cell proliferation. Mutations and dysregulation of the RAS-RAF-MEK-ERK signaling pathway are among…

Second HIV patient appears to have cured herself with natural immunity

Basic Science Program, Mary Carrington, Ph.D.Posted 3/15/2022
Frederick National Laboratory scientists were part of a multi-institutional collaboration that has identified a second patient whose natural immune response to HIV infection appears to have cured her of the disease, raising the question: Can this be replicated? Only three other patients have ever been declared fully cured, but each of these outcomes was accomplished…

Cancer researchers invited to apply for new cryo-EM training program

National Cryo-Electron Microscopy Facility, NCEF Cryo-EM Training ProgramPosted 3/9/2022
The Frederick National Laboratory will host a new training program in Frederick, Maryland, September 12-16 for cancer researchers who want to build expertise in cryo-electron microscopy (cryo-EM). Cryo-EM is a microscopy technique where samples are flash-frozen and bombarded with electrons to generate images. The resulting high-resolution images are helping cancer…

Columbia University students employ AI to predict chemical properties in hands-on drug discovery project

Cancer Data Science Initiatives, Partnership Development OfficePosted 2/28/2022
Seven Columbia University graduate students recently completed drug discovery projects at the Frederick National Laboratory for Cancer Research (FNL) as part of their fall 2021 semester. Since 2020, 40 Columbia University students have completed projects with the FNL for their master’s degree coursework. The projects represent a partnership between Columbia University’s…