Technologies invented and patented by researchers at the Frederick National Laboratory for Cancer Research cross the breath of the FNL’s research in cancer and HIV/AIDS. 

Most of these patents are owned by the government and the technologies are available for licensing from the National Cancer Institute's Technology Transfer Center.  

Contact(s)
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Contact Claudia Haywood, J.D., with questions at claudia.haywood@nih.gov.

34 patents filed to date.

Patent No. 

Title 

FNL Inventors 

US 9,631,192 

Auto-recognizing therapeutic RNA/DNA chimeric nanoparticles (NP) 

Eckart Bindewald, Ph.D.  
Mathias Viard, Ph.D. 

US 9,796,967 
 

Compositions related to controllable intervening protein sequences (CIPS) comprising reversible zinc-binding motifs and inteins 

Jianwei Zhu, Ph.D.  
David Nellis, MS 

US 9,540,471 

Nitric oxide-releasing diazeniumdiolated polyvinylpyrrolidone-based polymers, and compositions, medical devices, and uses thereof 

Joseph Hrabie, Ph.D. 

US 9,644,037 

Antibodies that specifically bind ataxia telangiectasia-mutated and RAD3-related kinase phosphorylated at position 1989 and their use 

Thomas Pfister, Ph.D. 
Allison Marrero, Ph.D. 
Robert Kinders, Ph.D. 
Ralph Parchment, Ph.D. 

US 10,954,492 

Processes for production and purification of nucleic acid-containing compositions 

Jianwei Zhu, Ph.D. 
Samir Shaban, MS 
Yueqing Xie, Ph.D. 
Trevor Broadt, MS 
George Mitra, Ph.D. 

US 10,517,890 
 

Triggering RNA interference with RNA-DNA and DNA-RNA nanoparticles 

Mathias Viard, Ph.D. 

US 10,711,068 
 
 

Anti-CD133 monoclonal antibodies and related compositions and methods 

Thomas Pfister, Ph.D. 
Robert Kinders, Ph.D.  
Tony Navas, Ph.D. 

US 10,329,323 
 
 

Method for purifying antibodies using PBS 

Samir Shaban, MS 
Mary Koleck, Ph.D. 
George Mitra, Ph.D. 

US 10,662,464 

Methods of analyzing virus-derived therapeutics 

Trevor Broadt, MS 

US 11,174,292 

Substitutions-modified prefusion RSV F proteins and their use 

Yaroslav Tsybovsky, Ph.D.  
Ulrich Baxa, Ph.D. 

US 10,961,283 
 
 

Self-assembling insect ferritin nanoparticles for display of co-assembled trimeric antigens 

Yaroslav Tsybovsky, Ph.D.  
Ulrich Baxa, Ph.D. 

US 10,857,140 
 
 

K-Ras modulators 

Anna Maciag, Ph.D. 
Oleg Chertov, Ph.D.  
David Turner, Ph.D. 

US 10,849,912 

Method of sensitizing cancer cells to the cytotoxic effects of apoptosis inducing ligands in cancer treatment 

Alan Brooks, MS 
Curtis Henrich, Ph.D. 
Thomas Sayers, Ph.D.  
Poonam Tewary, Ph.D. 

US 11,246,881 
 

Nanoparticle to target cancer 

Abdullah Mahmud, Ph.D.  
Stephan Stern, Ph.D. 

US 11,358,940 

K-Ras modulators 

Anna Maciag, Ph.D. 
David Turner, Ph.D. 
Marcin Dyba, Ph.D. 
Joseph Saavedra, Ph.D.  
Vandana Kumari, Ph.D. 

US 11,340,219 

Anti-pY1235-MET immunological binding reagent 

Apurva Srivastava, Ph.D. 
Thomas Pfister, Ph.D. 
Tony Navas, Ph.D. 
Ralph Parchment, Ph.D. 

US 11,512,313 

Functionally-interdependent shape switching nucleic acid nanoparticles 

Eckart Bindewald, Ph.D. 
Marina Dobrovolskaia, Ph.D.  
Mathias Viard, Ph.D. 

US 11,029,418 
 

Micro-dose calibrator 

Stephen Adler, Ph.D. 

US 10,633,370 
 
 

Phenyl indole allosteric inhibitors of p97 ATPase 

William Moore, Ph.D. 
Neal Green, Ph.D. 
Eric Baldwin, Ph.D. 

US 10,351,532 
 
 

Small molecule inhibitors of lactate dehydrogenase and methods of use thereof 

William Moore, Ph.D. 

US 10,001,483 

Methods for the treatment of Kaposi's sarcoma or KSHV-induced lymphoma using immunomodulatory compounds, and uses of biomarkers 

Denise Whitby, Ph.D. 

US 10,117,942 

Photoactivatable lipid-based nanoparticles as vehicles for dual agent delivery 

Mathias Viard, Ph.D. 

US10,464,970 

Compounds that bind to human immunodeficiency virus rev response element 

Ping Yu, M.S. 

US10,711,068 

Anti-CD133 monoclonal antibodies and related compositions and methods 

Thomas Pfister, Ph.D.,  
Robert Kinders, Ph.D., 
Tony Navas, Ph.D. 

US10,556,916 

Zirconium-89 oxine complex as a cell labeling agent for positron emission tomography 

Gary Griffiths, Ph.D. 

US11,078,239 

Prefusion PIV F immunogens and their use 

Yaroslav Tsybovsky, Ph.D. 

US10,809,268 

Methods and kits for measuring and quantifying DNA double-stranded breaks using gamma-H2AX and H2AX 

Yiping Zhang, Ph.D., 
Jiuping Ji, Ph.D. 

US9,738,726 

HER2-specific monoclonal antibodies and conjugates thereof 

Boopathy Ramakrishnan, Ph.D. 

US10,607,717 

Method for subtyping lymphoma types by means of expression profiling 

Paul Williams, Ph.D.,
Chih-Jian Lih, Ph.D. 

US10,301,621 

Multifunctional RNA nanoparticles and methods of use 

Mathias Viard, Ph.D. 

US9,874,622 

Hyperpolarized media transport vessel 

Marcelino Bernardo 

US10,954,228 

1 H-pyrazol-1-yl-thiazoles as inhibitors of lactate dehydrogenase and methods of use thereof 

William Moore, Ph.D. 

US11,313,772 

Fixatives and methods of use 

Candice Perry

US8,613,934 

Cellular and viral inactivation 

Julian Bess, Jr., M.S.,  
Yossef Raviv, Ph.D.,
Mathias Viard, Ph.D.