The Human SARS-CoV-2 Serology Standard is a pool of plasma from four donors with antibodies IgM and IgG to the SARS-CoV-2 spike and nucleocapsid proteins. The U.S. standard has been calibrated to the WHO International Standard.  

The goal of a serology standard is to harmonize assays that measure anti-SARS-CoV-2 antibodies and to enable comparisons between different studies, including different candidate COVID-19 vaccines. This serology standard is to be used for calibration purposes by laboratories conducting SARS-CoV-2 serology testing, rather than for routine inclusion as a quality control.

Additional Contact Info

Email with the request form and/or questions.

Researcher Resource

Request the serology standard

Download the request form and submit it to

Development and assays

This standard has been assigned ligand binding assay units and neutralizing units based on a collaborative study from eight different laboratories and several types of assays: 

  • Automated chemiluminescence 

  • Manufacturer developed ligand binding 

  • In-house developed ligand binding 

  • Fluorescence reduction neutralization