Program
The Protein Expression Laboratory generates DNA, cell line, and protein reagents for biomedical research from basic science to drug discovery. The team uses cutting-edge protein production technologies to generate proteins using bacteria, insect cells, or mammalian cells at scales from micrograms to grams.
Quality control is a major emphasis…
The Protein Expression Laboratory generates DNA, cell line, and protein reagents for biomedical research from basic science to drug discovery. The team uses cutting-edge protein production technologies to generate proteins using bacteria, insect cells, or mammalian cells at scales from micrograms to grams. Quality control is a major emphasis of…
News
The Frederick National Laboratory for Cancer Research (FNL) not only tackles some of the world’s greatest biomedical challenges but also serves as a shared national resource to enable high-quality research beyond its walls. One way FNL does this is through the Technical Services Program.
The Technical Services Program gives investigators…
Program
The Advanced Cryo-Electron Microscopy Technology Group explores emerging imaging platforms and develops methodologies, focusing on projects with the potential to make cryo-EM a more widely accessible technique. The team focuses on single-particle analysis and cryo-electron tomography.
Pushing resolution limits
Our group aims to push…
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The Advanced Cryo-Electron Microscopy Technology Group explores emerging imaging platforms and develops methodologies, focusing on projects with the potential to make cryo-EM a more widely accessible technique.
The team focuses on single-particle analysis and cryo-electron tomography. Our group aims to…
Program
The National Cryo-Electron Microscopy Facility provides extramural cancer researchers access to the latest technology for high-resolution imaging.
The National Cancer Institute launched the National Cryo-EM Facility in May 2017 as a federally funded pilot effort to help meet the needs of cancer researchers in United States academic laboratories…
The National Cryo-Electron Microscopy Facility provides cancer researchers access to the latest technology for high-resolution imaging.
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Program
The Imaging Mass Cytometry Laboratory provides cancer researchers with high-dimensional imaging analysis of tumor tissue samples at subcellular resolution.
In contrast to traditional imaging technologies, such as immunohistochemistry and immunofluorescence, which are capable of staining just two or three protein markers, imaging mass cytometry…
The Imaging Mass Cytometry Laboratory provides cancer researchers with high-dimensional imaging analysis of tumor tissue samples at subcellular resolution.
We work with researchers interested in studying the tumor microenvironment, tumor-stromal cells interactions, and the roles of different subpopulations of immune cells in tumor progression and…
Program
We provide comprehensive preclinical characterization of nanomedicine formulations. Our work encompasses physicochemical characterization as well as in vitro and in vivo immunological, pharmacological, and toxicological evaluations.
Exploring new strategies for nanotech drug development
The laboratory has characterized hundreds of…
The Nanotechnology Characterization Laboratory provides comprehensive preclinical characterization of nanomedicine formulations, encompassing physicochemical characterization as well as in vitro and in vivo immunology, pharmacology and toxicology evaluation.
The laboratory has characterized hundreds of unique nanomedicine formulations and has…
Program
The Antibody Characterization Laboratory is a reference program that develops antibodies for the scientific community, including extensive antibody characterization data and protocols.
The laboratory uses an array of techniques to determine the properties of antibodies and other renewable reagents that can be used in cancer-related research.…
The Antibody Characterization Laboratory is a reference program that develops antibodies to be made available to the scientific community, including extensive antibody-characterization data and protocols.
The laboratory uses an array of techniques to determine the properties of antibodies and other renewable reagents that can be used in cancer-…
Program
The CLIA Molecular Diagnostics Laboratory supports cancer- and disease-related research by validating genetic mutation detection, DNA sequencing, and gene expression technologies for researchers, as well as examining human specimens to provide health assessment, prevention, diagnosis, and disease treatment information to interested parties.
We…
The CLIA Molecular Diagnostics Laboratory makes clinical Sanger sequencing, genetic mutation detection, and gene expression technologies available to researchers.
We strive to support cancer and other disease-related research by providing access to cutting-edge technologies and specialized services, including nucleic acid extraction, fragment…
News
Researchers from the Sequencing Facility and Biomedical Informatics and Data Science Directorate at the Frederick National Laboratory (FNL) collaborated with the U.S. Food and Drug Administration (FDA) and other research centers across the U.S. to conduct a benchmark study establishing best practices for high-throughput single-cell RNA sequencing…
News
The Frederick National Laboratory (FNL) is providing scientists across the country with a key antigen used in antibody tests for the coronavirus after finding that the antigen is exceptionally sensitive and can be made rapidly and at low cost. This helps meet a pressing need for accurate testing.
The antigen, a protein, is used in blood…
