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HIV/AIDS Research

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An anti-HIV antibody called VRC01 does not protect people from acquiring HIV, according to findings from the Antibody-Mediated Prevention (AMP) Trials. The results were recently reported in the New England Journal of Medicine. While they indicate that this antibody alone is not a strong HIV-prevention measure, the data suggest that antibodies…
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Researchers are launching a new project aimed at understanding vaginal transmission of HIV and examining what happens in the earliest stages of infection in people with a cervix, who represent about one-fifth of new cases each year. Christine Fennessey, Ph.D. and Claire Deleage, Ph.D. in the Frederick National Laboratory’s AIDS and Cancer…
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Victor Ssempijja remembers there being many fatherless households in his hometown in Uganda during his childhood. In fact, he says he could count the number of complete families on just his fingers. The other fathers had died of HIV and associated complications. “I actually grew up thinking that men were not supposed to live long,” he said…
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A new advance in our understanding of HIV comes from what Steve Hughes, Ph.D., calls “an odd observation.” Certain people living with HIV had only partially suppressed levels of virus in their blood despite being on effective antiretroviral therapy (drugs used to manage HIV). At first, an explanation seemed like it would be simple—but it wasn’…
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FREDERICK, Md. -- Recent scientific papers co-authored by researchers at the Frederick National Laboratory for Cancer Research present novel discoveries about HIV and one similar infection from three fields of inquiry about the virus, all with the potential to further discoveries leading to prevention or treatment of HIV infection. The papers…
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In the immunology lab at Stanford Hospital there was a sense of urgency to discover the culprit of the strange disease that caused rare cancers and infections, initially diagnosed among gay men. It was 1983, and the first signs of what would become the AIDS threat were outlined in a series of reports from the Centers for Disease Control and…
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FREDERICK, Md. -- It has been used in clinical studies on four continents and has been tested in thousands of volunteers. It was produced at the Frederick National Laboratory for Cancer Research over a five-year span to meet increasing clinical demand, and it may play an ongoing role in the future of HIV research. The investigational product,…