Biopharmaceutical Capabilities

Overview

Since its inception, the Biopharmaceutical Development Program has manufactured more than 250 lots of 100 different biopharmaceuticals to support human clinical studies, including:

  • Proteins and peptides
    • Recombinant proteins
    • Monoclonal antibodies (murine/humanized/chimeric)
    • Immunotoxins
    • Cytokines
    • Immunocytokines
  • Nucleic acids
    • Oligonucleotides
    • Plasmid products
    • DNA vaccines
    • Double-stranded DNA decoy
  • Adjuvant forumulations
  • Vectors and vaccines
    • Herpesvirus
    • Adenovirus
    • Poliovirus
    • Vaccinia
  • Whole-cell products

Focus

Cancer Therapeutic/Preventative Vaccine Products 

  • AdGMCA9 Adenovirus 

  • AdhAFP Adenovirus 

  • Bradykinin-Antagonist Peptide 

  • H1299 Cell Bank 

  • H929, U266 Cell Banks 

  • HPV16 L2E6E7 Recombinant Fusion Protein 

  • MART-1 Peptide Vaccine 

  • Pancreatic Tumor Cell Bank 

  • Patient specific Id Vaccine 

  • phGM-CSF Plasmid DNA 

  • pING-mTYRP2 Plasmid DNA 

  • pNGVL4a-CRT/E7(detox) Plasmid DNA 

  • pNGVL4a-Sig E7 Plasmid DNA 

  • Recombinant GP100 & HSP110 Complexed Vaccine 

  • Tumor Mutation Peptide Vaccines (multiple various) 

Gene Therapy Vectors 

  • AAV2-AADC 

  • AAV9-microdystrophin 

  • AAV9-PCCA 

  • IL-12 Lentivirus 

Immunotoxins 

  • 3D1-MMAE, Anti-MUC1-C ADC 

  • BL-22 dsFv RFB4-PE38, Anti-CD22 

  • ERB-38, Anti-HER2 

  • HA-22, Anti-CD22 

  • LMB-2, Anti-TAC Fv PE-38 

  • MR1-1 scFv-PE38, Anti-EGFRvIII 

  • RN321-RFB4 Onconase 

Immunomodulators 

  • 11B11 RAT, Anti-muIL-4 

  • AdCCL-21 

  • CD40 Ligand 

  • cGMP Endotoxin 

  • IL-2 (Recertification) 

  • IL-2/Fc 

  • IL-4 (Recertification) 

  • IL-6 (Recertification) 

  • Monophosphoryl Lipid A (MPL) 

  • Mutant IL-15/Fc 

  • rhIL-12 

  • rhIL-15 (E. coli) 

  • rhIL-15/Rα (Mammalian) 

  • rhIL-7 (mammalian) 

  • rhIL-7(E. coli) 

Infectious Disease Vaccine Products 

  • Conjugated Malaria Vaccine Antigen and Carrier Protein 

  • EBV Supernatant 

  • F1-V Recombinant Protein 

  • Gp350(EBV)-Ferritin + gH/gL/gp42(EBV)-Ferritin Virus-like Particles 

  • Malaria Vaccines & CPG Adjuvant Formulation + Fill/Finish 

  • MVA-CMV Vaccinia 

  • Padre/Tetanus CMV Peptides 

  • rPA Recombinant Protein 

  • rSEB Recombinant Protein 

  • VEE Alpha Virus 

Monoclonal Antibodies 

  • 11B.11, Rat Anti-Murine IL-4 

  • 1A7, Anti-Id GD2 

  • 1D12, Anti-hu IgM 

  • 2A11, Anti-Bombesin 

  • 7G7, Anti-IL-2 alpha R CD25 

  • 95-5-49, Anti-T-cell 

  • 95-6-22, Anti-T-cell 

  • Anti-CD45RA 

  • Anti-CD54 

  • Anti-transferrin scFv 

  • ATI-1013, Anti-Nicotine 

  • Bu 12-Saporin, 4KB128-Saporin, OKT10-Saporin 

  • Ch 11-1F4, Anti-Ig Kappa light-chain 

  • Ch 14.18, Anti-GD2 

  • Ch 45H1, Anti-canine CTLA 

  • Ch EB6, Anti-hu IgA 

  • ChR24, Anti-GD3 

  • D61,2, Anti-Colon Cancer 

  • F-5 CYS, Anti-HER2/neu 

  • Ganitumab, Anti-IGF-1R 

  • hAnn A1, Anti-human Annexin-A1 

  • HD37, Anti-CD19 

  • HeFi-1, Anti-CD30 

  • hJAA-F11, Anti-Thomsen-Friedenreich glycoantigen 

  • HOKT Gamma 1 (ala, ala), Anti-CD 30 

  • Hu 14.18 IL-2 Fusion Protein, Anti-GD2 

  • Hu B3, Anti-Ley-carbohydrate 

  • Hu HB22.7, Anti-CD22 

  • Hu MiK Beta 1, Anti-IL2 Receptor 

  • HuATN-658, Anti-uPAR 

  • HuCC49-Delta-CH2, Anti-Tag 72 

  • LEC/NHS76 (PB3), Anti-DNA/Histone HI-LEC fusion 

  • MRK-16, Anti-human P-glycoprotein 

  • Mu 11-1F4, Anti-Ig Kappa light-chain 

  • OVB3, Anti-OVCAR-3 

  • Panitumumab-IRDye800, Anti-EGFR 

  • RFB4, Anti-CD22 

  • VH4-34 IgM216, Anti-B cell lactosamine 

Oncolytic Viruses 

  • Ad Cox-2 / RGD Tissue Specific CRAd 

  • Ad5/3 Delta-24 Adenovirus 

  • Ad5RGDCD/SSTR Adenovirus 

  • Ad5RGDTK/SSTRTK Adenovirus 

  • Ad-KD3 Adenovirus 

  • AdTSTA-sr39TK Adenovirus 

  • Delta-24RGD Adenovirus 

  • GM-CSF-CAIX Fusion Adenovirus 

  • HSV-C134 Herpes Virus 

  • MO32 Herpes Virus 

  • MV-NIS Measles Virus 

  • PVS-RIPO Polio Virus chimera 

  • rRp450 Herpes Virus 

Recombinant Proteins and Natural Products 

  • Geldanamycin 

  • Hynicanexin-rh-Annexin V (Recertification) 

  • RLIP76 Recombinant Ion Transporter 

  • Shepherdin 

  • TTHX1114 Recombinant FGF-1 

  • Wolinella Asparaginase 

Therapeutic Cellular Products 

  • CD33 CART 

  • GD2 CART 

  • ICBP 50 Human Breast Cell Lines 

Therapeutic Oligonucleotides 

  • C-myb Antisense 

  • GQ-ODN T40214 

  • IGF-1R Antisense 

  • KSR Antisense 

  • STAT-3 Decoy