Content tagged as

Clinical Research

News
A new clinical study in Africa is testing an antiviral treatment for patients with mpox (previously known as monkeypox). This is the latest project for the Frederick National Laboratory for Cancer Research’s Clinical Monitoring Research Program, which specializes in supporting clinical trials in domestic and international settings.   The…
News
People with HIV on long-term antiretroviral therapy show signs of brain damage and cognitive impairment on a battery of imaging, laboratory, and functional tests, and they report a greater degree of difficulty with the routine tasks of everyday life, according to a new study. The study, published in April in the journal Neurology, is the first…
News
A research group that includes scientists from the Frederick National Laboratory for Cancer Research has shown that an experimental vaccine designed to simultaneously protect against malaria, Zika, and a host of other mosquito-borne diseases safely provokes a strong immune response when tested in human volunteers. The next step will be to see if…
Program
The HPV and COVID-19 Serology Laboratories are world leaders in the development, validation, and standardization of serology assays for HPV and COVID-19. These laboratories develop standards and reference reagents that enable scientists to compare data derived from different studies and vaccines. Serology standards enable data comparison…
Image The COVID-19 Serology Laboratory establishes standards and coordinates research for the National Cancer Institute Serological Sciences Network (SeroNet).   At the start of the COVID-19 pandemic in March, 2020, our scientists pivoted to evaluate the performance of SARS-CoV-2 antibody tests for the U.S.…
News
The National Institutes of Health (NIH) awarded three Frederick National Laboratory teams with NIH Director’s Awards for innovative approaches to COVID-19-related research that advances knowledge and enhances health. “It is a tremendous honor for three Frederick National Laboratory teams to be nominated by three distinct entities within NIH…
News
In the push to find treatments for the novel coronavirus, a Frederick National Laboratory team helped enroll thousands of participants in clinical trials and brought on board community hospitals as new study sites to join the research effort amid the pandemic. The partnership with community-based hospitals as clinical trial sites was…
News
A grim statistic is driving Steven Rosenberg’s mission to find new cancer treatments—and his partnership with Frederick National Laboratory (FNL) to do so. “Every year in the United States, about 600,000 people die of cancer, 90% of whom die of the solid epithelial cancers,” said Rosenberg, the M.D., Ph.D., chief of the National Cancer…
Program
Since its inception, the Biopharmaceutical Development Program has manufactured more than 250 lots of 100 different biopharmaceuticals to support human clinical studies, including: Proteins and peptides Recombinant proteins Monoclonal antibodies (murine/humanized/chimeric) Immunotoxins Cytokines Immunocytokines Nucleic acids…
Program
The Virus Isolation and Serology Laboratory performs virus detection and quantification, sample genotyping, and sequential serology tracking studies for the National Institute of Allergy and Infectious Diseases. We carry out serologic and molecular testing to monitor treatment and natural history trials for HIV, SARS-CoV-2, influenza virus, and…
The Virus Isolation and Serology Laboratory performs sequential serologic, virus detection and quantification, and genotyping studies for the National Institute of Allergy and Infectious Diseases.   The results of these studies provide information to further research and support ongoing drug efficacy and epidemiology studies.   The Virus…
Program
The Neutrophil Monitoring Laboratory assesses neutrophil dysfunction in patients with different primary immunodeficiencies. Our CLIA-certified laboratory develops and performs high-complexity assays to analyze and evaluate biological specimens for neutrophil activity and various inflammatory mediators or cytokines. We provide clinical,…
The Neutrophil Monitoring Laboratory performs testing to assess neutrophil dysfunction in patients with various primary immunodeficiencies.  We develop state-of-the-art assays to evaluate a variety of neutrophil functions such as reactive oxygen species production, chemotaxis, cell shape change and spreading, exocytosis, and alterations in…