Posted 3/25/2024
Scientists and clinicians whose discoveries have shaped the understanding of HIV disease will provide updates on the...
Posted 2/22/2024
There are many paths for women to travel to find success in science. That was a crucial theme conveyed by the four...
Posted 2/7/2024
Frederick National Laboratory researchers identified a vitamin A derivative (retinoid) that when combined with a...
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Targeting Hidden Reservoirs of the AIDS Virus for Eradication
AIDS and Cancer Virus ProgramPosted 6/26/2016
Frederick National Lab scientists have developed a faster, more accurate way of pinpointing minute pockets of the AIDS virus that can hide out in infected tissue, thus exposing these remnants as targets for more definitive treatment of the infection.
Current antiretroviral drug treatments targeting the AIDS-causing human immunodeficiency virus (HIV) can effectively…
Frederick National Lab Collaborates with Moffitt Cancer Center on HPV and Oral Cancer
Posted 6/9/2016The Frederick National Lab and Moffitt Cancer Center have established a collaboration to research antibody responses against the human papillomavirus (HPV) in males following administration of the Gardasil vaccine. The vaccine prevents HPV infections that can cause a number of cancers, including oral cancers.
HPVs—especially HPV 16—cause approximately 70 percent of cancers…
Collaboration with Pharma Will Introduce Nanotechnologies in Early Stage Drug Development
Nanotechnology Characterization LaboratoryPosted 6/2/2016The Frederick National Lab has begun to assist several major pharmaceutical companies in adopting nanotechnologies in early stage drug development, when the approach is most efficient and cost-effective.
For some time, the national lab’s Nanotechnology Characterization Laboratory (NCL) has worked with pharmaceutical companies on reformulating cancer drugs that failed in…
Girls in Technology Essay Contest Winner Spends a Day in the Life of a Scientist
Posted 1/20/2016Sixteen-year-old Celina Paudel solidified her career interest in biomedical engineering after winning a scholarship through the national Girls in Technology (GIT) program. Then, thanks to Rachel Bagni, she got to see what it really means to be a scientist.
Bagni, Ph.D., head scientist of the Target Biology Group, Cancer Research Technology Program, played the role of mentor…
European Nanotechnology Experts Visit NCL; Harmonize Best Practices for Nanomedicine Collaboration in Europe
Posted 1/18/2016European nanotechnology experts visited the Nanotechnology Characterization Laboratory (NCL) to observe best practices and methods and to share their own knowledge with NCL scientists as they prepared to launch an NCL-like operation in Europe.
The European Union Nanomedicine Characterisation Laboratory (EU-NCL) plans to open for business in mid-2016 with funding from the…
RAS Symposium Draws Hundreds of Attendees
Posted 1/5/2016
They call themselves “rasologists”: scientists who study the RAS family of genes and the cancers that can arise due to mutations within them. This field of research is at the heart of some sobering numbers. Almost a third of all human cancers, including 95 percent of pancreatic cancers, are driven by mutated RAS genes. The American Cancer Society estimates there were 48,…
Crystal Structure of Protein Reveals Target for Drugs Against Lethal MERS Virus
Posted 11/15/2015
A research team of scientists from the National Cancer Institute and the Frederick National Laboratory for Cancer Research recently identified the structure of a key protein of the virus that causes the highly lethal Middle East Respiratory Syndrome. The team is now using that discovery in the search for new drugs.
The Middle East Respiratory Syndrome coronavirus (MERS-…
Lab Plays Central Role in Groundbreaking National Clinical Trial in Precision Medicine
Molecular Characterization LaboratoryPosted 9/16/2015The Molecular Characterization Laboratory at the Frederick National Laboratory for Cancer Research lies at the heart of an ambitious new approach for testing cancer drugs that will use the newest tools of precision medicine to select the best treatment for individual patients based on the genetic makeup of their tumors.
The protocol, called NCI-Molecular Analysis for…
FNL Scientists and Collaborators Solve 3-D Structure of Key Protein in Alzheimer’s Disease
Posted 6/15/2015Researchers at the Frederick National Lab (FNL) have collaborated in solving the three-dimensional structure of a key protein in Alzheimer’s disease, providing new insight into the basic mechanisms that give rise to the devastating illness.
The protein—amyloid-beta(1-42)—is the initial and most common protein that builds up layer by layer in spaces between nerve cells of…
New Breed of Mice May Improve Accuracy for Preclinical Testing of Cancer Drugs
Laboratory Animal Sciences ProgramPosted 5/5/2015A new breed of lab animals, dubbed “glowing head mice,” may do a better job than conventional mice in predicting the success of experimental cancer drugs—while also helping to meet an urgent need for more realistic preclinical animal models.
The mice were developed to tolerate often-used light-emitting molecules, such as luciferase from fireflies and green fluorescent…
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