Researchers from the AIDS and Cancer Virus Program (ACVP) work to improve the diagnosis, prevention, and treatment of HIV infection, AIDS, and AIDS-related tumors, including cancer causing viruses such as KSHV, through basic and applied research. The program today directly stems from scientists who, in 1984, helped contribute to the first generation of AIDS blood screening tests that helped prevent further spreading of the newly identified AIDS virus throughout the U.S. blood supply.
The ACVP consists of highly collaborative investigator-headed research sections conducting investigator-initiated research and research core support laboratories. Program scientists conduct and support AIDS studies through research including fundamental molecular virology, in vitro studies, nonhuman primate models, and performing and supporting clinical and epidemiological studies in the U.S. and internationally. As an explicit feature of its mission as a part of the Frederick National Laboratory, the ACVP also develops and proactively shares unique and cutting edge technologies with the broader research community to facilitate overall research progress.
- Genetically-barcoded SIV facilities enumeration of rebound variants and estimation of reactivation rates in nonhuman primates
- Kaposi's sacroma-associated herpesvirus polyadenylated nuclear RNA: a structural scaffold for nuclear, cytoplasmic and viral proteins
- Evidence for a mesothelial origin of body cavity effusion lymphomas
- Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent-reservoir dynamics
- Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir
Image: Immunofluorescence staining of HIV viral RNA (red), CD8+ T cells (green) and B cells (blue) in a lymph node section from an HIV+ subject (inset is an enlargement (14×) of the area outlined in the main image) demonstrating that follicular TC cells localize within B cell follicles and are in close proximity to HIV-infected vRNA+ cells, suggesting they might have a role in limiting the infection in B cell follicles (Leong YA, et al. CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles. Nat Immunol. 2016 Oct;17(10):1187-96. doi: 10.1038/ni.3543. Epub 2016 Aug 3. PMID: 27487330).