Retroviral Pathogenesis Section (RPS)

Overview

The Retroviral Pathogenesis Section conducts both in vitro and in vivo studies aimed at improving our understanding of the basis of lentiviral pathogenesis, particularly those aspects relevant to the development and evaluation of effective means of preventing and treating HIV infection and AIDS. The work spans a broad scope from in vitro studies of the structure of viral molecules involved in infection, to the interaction of viral particles with immune system cells, to in vitro studies, to in vivo studies in non-human primate models. The work emphasizes both applied studies such as the in vitro and in vivo evaluation of candidate vaccine and treatment approaches (immunogens, adjuvants, modes of immunization) and more basic studies aimed at characterizing fundamental processes of virus/host interactions potentially relevant to prevention and treatment. Areas of particular interest include development and application of improved non-human primate models involving minimally chimeric HIV strains, non-human primate models for evaluating virus suppressive antiretroviral drug treatment and approaches for targeting residual virus and latently infected reservoirs in treated individuals, the dynamics of virus/host interactions during primary infection, and characterization of the virus/host interactions associated with situations of effective host control of replication, including vaccine induced protection.

Complete publications list

Retroviral Pathogenesis Section Staff

Jeffrey Lifson, M.D. Jeffrey D. Lifson, M.D.
Prinicipal Investigator
Phone: 301-846-1408
Fax: 301-846-5588
Email: lifsonj@mail.nih.gov

  • Wang, Yichuan
  • Swanstrom, Adrienne
  • Hill, Brenna
  • Li, Yuan
  • Schneider, Douglas
  • Trivett, Matthew