Protection against Human Papillomavirus (HPV) infection after vaccination is believed to be mediated by HPV-specific antibodies. Antibody responses in HPV prophylactic vaccine trials have been assessed using different methods.
The lack of standardized assays, procedures, and reagents accessible to the scientific community has precluded the comparison of different studies evaluating immunogenicity of HPV vaccines.
The HPV Serology Laboratory at the Frederick National Laboratory was established in January 2017 to address some of these needs and advance HPV assay standardization. The HPV Serology Laboratory, now the Serology Laboratory, leads an HPV Serology Standardization initiative in collaboration with the National Cancer Institute and the Bill and Melinda Gates Foundation.
We invite you to download and use the following standard operating procedures in your own serology laboratory.
Standard Operating Procedures
General Laboratory Procedures
Note: Procedures should only be used as guidance documents and not substituted for your own institute's/organization's/government's policies.