The AIDS and Cancer Virus Program works to improve the prevention, diagnosis, and treatment of HIV infection and AIDS-related tumors through basic, applied, and translational research, including development and sharing of novel experimental models, reagents and analytical methods.
Through investigator-driven research and extensive collaborations between our research sections and research support cores with scientists within and outside the National Institutes of Health, our researchers address key remaining challenges in the prevention and treatment of HIV infection and associated conditions.
To improve HIV prevention, the AIDS and Cancer Virus Program pursues both innovative vaccine and non-vaccine approaches. Some of our studies focus on:
- Developing novel models, reagents, and approaches for in vivo models to study key aspects of how AIDS viruses infect susceptible individuals and cause disease, identifying potential targets for intervention.
- Evaluating new antiretroviral drugs, vaccines, and immunotherapies.
- Understanding how other viruses, such as KSHV, can cause malignancies in the setting of AIDS virus induced immunosuppression.
Much of the work involves the development and application of novel nonhuman primate models, including construction of “designer viruses” that provide new insights into disease mechanisms and approaches to prevention and treatment.
The program also develops and shares research materials and experimental models with the HIV research community.