HIV plays a direct role in causing blood cell cancers in rare instances, says a new study of HIV and tumor DNA.…

The spike protein critical for coronavirus research -- and for some COVID-19 vaccines -- slowly…

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FNL supports website development for official COVID-19 treatment guidelines

Posted 5/28/2020
As COVID-19 spread around the U.S., health care providers needed guidelines to treat patients—and they needed them fast.

The solution? A website that would house data- and expert-backed clinical treatment guidelines devised by a panel of U.S. physicians, statisticians, and other experts from the National Institutes of Health (NIH), universities, and health care…

Ebola clinical trial supported by FNL receives “Trial of the Year” award

Posted 5/26/2020
The Pamoja Tulinde Maisha (PALM, Kiswahili for “together save lives”) trial, a large Ebola research effort supported by the Frederick National Laboratory, has received the David Sackett Trial of the Year Award for 2019.


Ian Crozier, M.D., Frederick National Laboratory/NIAID, administers supportive care and an experimental treatment to a patient in one of…

Study on “rapid autopsy” tumor tissue as a valuable research tool is among abstracts presented at 2020 ASCO Virtual Scientific Program

Posted 5/25/2020
Tissue obtained from tumors during an autopsy conducted shortly after a cancer patient’s death provides unique insights into how the tumors evolved, spread and resisted treatment. The Frederick National Laboratory’s Molecular Characterization Laboratory reports on results of a study on preclinical models established from “rapid autopsy” tumors during the 2020 American Society…

The Frederick National Laboratory for Cancer Research and COVID-19 serology testing

Posted 5/5/2020
In its urgent efforts to confront the novel coronavirus, the U.S. Food and Drug Administration (FDA) has tapped the Frederick National Laboratory for Cancer Research (FNL) to scientifically inform its decision-making on potential approval of blood tests for the presence of antibodies to SARS-CoV-2.


The HPV Serology Laboratory team led by Dr. Ligia Pinto…

FNL Team Places Among Top Three in International Computing Contest

Posted 5/3/2020
Three employees from Frederick National Laboratory’s Imaging and Visualization Group recently claimed a top spot of a computing and artificial intelligence challenge that attracted 170 competing groups from around the world.

The team—Yanling Liu, Ph.D.; Hyun Jung, Ph.D.; and G. Tom Brown, M.D., Ph.D.—took third place overall and was the top group in the “…

FNL RAS Investigators Take Published KRAS Study a Step Further, Share Findings in PNAS Letter to Editor

Posted 4/27/2020
A scientific paper on a member of the RAS family of oncogenes published last summer so intrigued Frederick National Laboratory computational scientist Trent Balius that he and his and colleagues performed a follow-up study, shedding more light on the topic.

Balius and FNL colleagues in the National Cancer Institute’s RAS Initiative shared their findings as a…

Building an interdisciplinary pain medicine and palliative care program in Ethiopia

Posted 4/12/2020
Cancer is beginning to eclipse infectious disease as a major cause of mortality in low-to-middle income countries like those in sub-Saharan Africa. In Ethiopia, people with cancer who reach a hospital are diagnosed with advanced disease for which there is little treatment available and practically nothing to stem their unbearable disease-related pain. The Ethiopian government…

Building an interdisciplinary pain medicine and palliative care program in Ethiopia

Posted 4/12/2020
Cancer is beginning to eclipse infectious disease as a major cause of mortality in low-to-middle income countries like those in sub-Saharan Africa. In Ethiopia, people with cancer who reach a hospital are diagnosed with advanced disease for which there is little treatment available and practically nothing to stem their unbearable disease-related pain. The Ethiopian government…

Trans-NIH Study Shows HPV Vaccine Benefits Women Following Donor Stem Cell Transplant

Posted 2/27/2020
Immune Response Induced by Vaccination May Lower Risk of New HPV Infections and Associated HPV-Related Cancers in Post-Transplant Women

Women who completed a three-dose series of the HPV vaccine following a donor stem cell transplant developed a surprisingly robust immune response to vaccination, which was not significantly different from the responses in…

Frederick National Laboratory's Biopharma Development Program Set to Manufacture CAR-T Cell Therapy

Posted 2/18/2020
A team from the Frederick National Laboratory’s Biopharmaceutical Development Program is developing a new autologous cell therapy line that uses engineered chimeric antigen receptor (CAR) T cells to treat acute myeloid leukemia, a particularly aggressive form of pediatric blood cancer. This foray into cell immunotherapy represents a new avenue of research and development for…

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