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Biomedical Imaging

Computing collaboration makes massive microscopy analyses possible

News
On any given day, microscopist Susan Lea, D.Phil., and her team at NCI at Frederick collect more data than can fit on any standard hard drive, creating a challenge for data storage and analysis. Their average data collection is 5 terabytes, a quantity roughly 20 times the storage capacity of a 256-gigabyte laptop or the equivalent of storing…

Cancer researchers invited to apply for new cryo-EM training program

News
The Frederick National Laboratory will host a new training program in Frederick, Maryland, September 12-16 for cancer researchers who want to build expertise in cryo-electron microscopy (cryo-EM). Cryo-EM is a microscopy technique where samples are flash-frozen and bombarded with electrons to generate images. The resulting high-resolution…

NCEF Cryo-EM Training Program

Basic page
Overview Recent advances in cryo-EM technology have made it possible for scientists to obtain images and structures of proteins and macromolecular complexes in greater detail than ever before. This has created a surge in demand for cryo-EM experiments that has far outstripped the supply of instruments and cryo-EM trained workforce. As demand…

Nanotechnology enables potential novel imaging agent for early pancreatic cancer detection

News
Frederick National Laboratory (FNL) scientists, led by Stephan Stern, Ph.D., and their colleagues have created a novel imaging agent that, with further development, might detect deadly pancreatic cancer at its earliest, most-treatable stages and thereby improve the prognosis for patients. Pancreatic cancer has a high mortality rate because it…

Pilot study: PET imaging might improve prostate cancer diagnosis and treatment

News
A pilot study suggests a near real-time method of imaging prostate cancer to aid in organ-sparing treatments, and an innovative as well as accurate way to see whether the cancer has spread. These dual findings stem from research reported in Molecular Imaging and Biology on a relatively new radiotracer used in dynamic positron emission…

Coronavirus spike protein deteriorates during storage, but it can be restored

News
The spike protein critical for coronavirus research -- and for some COVID-19 vaccines -- slowly deteriorates while in storage, which can affect research results and vaccine production, a new study suggests. But the effect can be reversed. The SARS-CoV-2 spike protein, which is used in laboratories around the world, is unstable under…

Newly published metadata standards for biological imaging aim to make data sets more accessible

News
Meta tags are used on web pages. Metadata is added to photographs. Both help people find, use, and reuse these digital assets. Scientists say the same is needed for image data in biology, and urgently so. “A single imaging data set could be a thousand images,” said Frederick National Laboratory imaging scientist Kedar Narayan. “Someone might…

Radiochemistry Support Group

Program
The Radiochemistry Support Group develops radiochemical methods to produce radiotracers for in vivo imaging in HIV studies, and chemical and biochemical methods to synthesize, identify, and characterize the radiolabeled antibody, cytokine, and small molecular probes.  We develop radiotracers to support noninvasive, in-vivo whole-body imaging in…

Advanced Cryo-Electron Microscopy Technology Group

Program
Image The Advanced Cryo-Electron Microscopy Technology Group explores emerging imaging platforms and develops methodologies, focusing on projects with the potential to make cryo-EM a more widely accessible technique.  The team focuses on single-particle analysis and cryo-electron tomography. Our group aims to…

National Cryo-Electron Microscopy Facility

Program
The National Cryo-Electron Microscopy Facility provides cancer researchers access to the latest technology for high-resolution imaging.  Image Image…
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