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Biomedical Imaging

The spike protein critical for coronavirus research -- and for some COVID-19 vaccines -- slowly deteriorates while in storage, which can affect research results and vaccine production, a new study suggests. But the effect can be reversed. The SARS-CoV-2 spike protein, which is used in laboratories around the world, is unstable under…
Meta tags are used on web pages. Metadata is added to photographs. Both help people find, use, and reuse these digital assets. Scientists say the same is needed for image data in biology, and urgently so. “A single imaging data set could be a thousand images,” said Frederick National Laboratory imaging scientist Kedar Narayan. “Someone might…
The Radiochemistry Support Group develops radiochemical methods to produce radiotracers for in vivo imaging in HIV studies, and chemical and biochemical methods to synthesize, identify, and characterize the radiolabeled antibody, cytokine, and small molecular probes.  We develop radiotracers to support noninvasive, in-vivo whole-body imaging in…
Image The Advanced Cryo-Electron Microscopy Technology Group explores emerging imaging platforms and develops methodologies, focusing on projects with the potential to make cryo-EM a more widely accessible technique.  The team focuses on single-particle analysis and cryo-electron tomography. Our group aims to…
Image The National Cryo-Electron Microscopy Facility provides cancer researchers access to the latest technology for high-resolution imaging.  Our user facility addresses pressing national and regional needs for structural biologists to have access to advanced microscopes capable of supporting high-resolution…
The Imaging Mass Cytometry Laboratory provides cancer researchers with high-dimensional imaging analysis of tumor tissue samples at subcellular resolution. We work with researchers interested in studying the tumor microenvironment, tumor-stromal cells interactions, and the roles of different subpopulations of immune cells in tumor progression and…
Overview The electron microscopy laboratories at the Frederick National Laboratory explore emerging platforms and develop methodologies to make cryo-EM and volume EM more widely accessible techniques. Cryo-electron microscopy Cryo-electron microscopy (cryo-EM) allows high-resolution visualization of macromolecules in solution and…
The Laboratory Animal Sciences Program is a comprehensive resource for scientists performing animal-based research to better understand cancer, HIV/AIDS, and other infectious diseases. We provide veterinary care, regulatory support, and routine and specialized husbandry services. We offer an integrated portfolio of state-of-the-art research…
A data set doesn’t sound like a flashy scientific advance, but that impression belies a concept with the potential to enable eye-catching science. Such is the case with CEM500K, a new data set created by Kedar Narayan, Ph.D., and Ryan Conrad in the Center for Molecular Microscopy at Frederick National Laboratory. As reported in eLife last week…
Publicly available data sets related to COVID-19 are appearing in an unexpected place—the Cancer Imaging Archive (TCIA), a project of the Division of Cancer Treatment and Diagnosis of the National Cancer Institute. Since the start of the pandemic, researchers around the world have been racing to learn as much as possible about the virus—how it…