Available Strain Details

Strain Information
Common Strain Name: p53 LSL R172H Pricing and Ordering Information
Strain Nomenclature: 129S4-Trp53tm2Tyj/Nci
Animal State: Frozen Embryo & Frozen Sperm
Release Category (Required for MTA form): B3

Strain Description: These mice contain a point-mutant allele of Trp53 that can be activated by Cre-mediated recombination. The conditional allele, containing LoxP sites and a transcriptional/translational STOP sequence, is functionally equivalent to a null mutation.
Mutation Information
Mutation Type: Targeted
Gene Name: Transformation related protein 53
Gene Symbol: Trp53
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: 129S4
Approx. Generation: 26
Organ Site:
Additional Information
Cryopreservation Mating Scheme: EMBRYOS: The embryo cryopreservation mating scheme is 129S4 females x heterozygous males. SPERM: sperm was obtained from heterozygote males. When maintained as a live colony, breeder pairs were distributed as heterozygotes. Homozygotes are viable and fertile but have decreased fertility and die young. Easiest to maintain as heterozygotes.
Genotyping Information: Protocol 1: Allele: Trp53<tm2Tyj>
Donating Investigator: Dr. Tyler Jacks

Key Reference: Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT, Crowley D, Jacks T. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell. 2004 Dec 17;119(6):847-60. PMID: 15607980 [Pubmed Abstract]