Available Strain Details

Strain Information
Common Strain Name: Plzp lacZ/lacZ Pricing and Ordering Information
Strain Nomenclature: B6; 129S1-Zbtb32tm2Ppp>/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B3,C1

Strain Description: Homozygous mice are viable and fertile. Plzp-deficient mice display defects in cell cycle control and cytokine production by T cells. Plzp inactivation also disrupts hematopoietic stem/progenitor cell quiescence.
Mutation Information
Mutation Type: Targeted
Gene Name: Plzp
Gene Symbol: Plzp
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6;129S1
Approx. Generation: Homo
Organ Site:
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is homozygous x homozygous. When maintained as a live colony, breeder pairs were distributed as homozygotes. Average litter size is 8.
Genotyping Information: Protocol 1: Allele: Zbtb32<tm2Ppp/Nci>
Donating Investigator: Dr. Pier Paolo Pandolfi

Key Reference: Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis.Piazza F, Costoya JA, Merghoub T, Hobbs RM, Pandolfi PP.Mol Cell Biol. 2004 Dec;24(23):10456-69. PMID: 15542853 [Pubmed Abstract]

Sponsor: NIH R01 grants to Pier Paolo Pandolfi