Available Strain Details

Strain Information
Common Strain Name: Pdx-1-cre Pricing and Ordering Information
Strain Nomenclature: B6.FVB-Tg(Pdx1-cre)6Tuv/Nci
Animal State: Frozen Embryo & Frozen Sperm
Release Category (Required for MTA form): B2

Strain Description: Pdx-1-Cre mice exhibit a stochastic pattern of high-level Cre expression in the pancreas (Hingorani et al., 2003). When combined with Tyler Jacks' latent activatable K-ras allele, LSL-KrasG12D (Kras2, NCI Mouse Repository strain code 01XJ6), Pdx-1-Cre causes ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs). Some of these lesions progress to invasive and metastatic adenocarcinomas.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: Cre recombinase
Transgene Symbol: Cre
Promotor Name: Insulin promoter factor 1 (Ipf1, Pdx1)
Promotor Symbol: Ipf1, Pdx1
Current Genetic Background: B6.FVB
Approx. Generation: 23
Organ Site: Pancreas
Additional Information
Cryopreservation Mating Scheme: EMBRYOS: The cryopreservation mating scheme is C57BL/6 females x hemizygous males. SPERM: Sperm was obtained from hemizgyous males. When maintained as a live colony, breeder pairs were distributed as a hemizygote (male or female) x wildtype C57BL/6 (male or female). Average litter size is 7.
Genotyping Information: Protocol 1: Allele: Tg(Ipf1-cre)1Tuv
Donating Investigator: Andrew M. Lowy

Key Reference: Hingorani SR; Petricoin EF; Maitra A; Rajapakse V; King C; Jacobetz MA; Ross S; Conrads TP; Veenstra TD; Hitt BA; Kawaguchi Y; Johann D; Liotta LA; Crawford HC; Putt ME; Jacks T; Wright CV; Hruban RH; Lowy AM; Tuveson DA (2003). Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4, 437-450. PMID: 14706336 [Pubmed Abstract]