Available Strain Details

Strain Information
Common Strain Name: Men1 null, Men1deltaN3-8 Pricing and Ordering Information
Strain Nomenclature: FVB;129-Men1tm1.1Ctre/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B1

Strain Description: This strain carries a deletion of exons 3-8 in the multiple endocrine neoplasia, type 1 tumor suppressor gene. Mice heterozygous for the Men1tm1Ctre allele develop a phenotype very similar to the human MEN1 disease. By nine months of age pancreatic islets exhibit hyperplasia and insulin-producing islet cell tumors. Parathyroid adenomas are also seen. By sixteen months of age larger pancreatic and parathyroid tumors are found as well as tumors of the thyroid, adrenal cortex and pituitary. These tumors form as a result of loss of heterozygosity (LOH). Mice homozygous for the mutation die in utero at E11.5-12.5.
Mutation Information
Mutation Type: Targeted
Gene Name: Multiple endocrine neoplasia 1
Gene Symbol: Men1
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: 129;FVB
Approx. Generation:
Organ Site: All
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is FVB/N females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as a heterozygote (male or female) x wildtype mouse from the colony. This strain is maintained by crossing heterozygotes with wildtype mates from the colony, preferably not siblings in order to avoid inbreeding.
Genotyping Information: Protocol 1: Allele: Men1<tm1.1Ctre>
Donating Investigator: Dr. Judy Crabtree

Key Reference: Crabtree JS, Scacheri PC, Ward JM, Garrett-Beal L, Emmert-Buck MR, Edgemon KA, Lorang D, Libutti SK, Chandrasekharappa SC, Marx SJ, Spiegel AM, Collins FS. 2001. A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc Natl Acad Sci USA, 98: 1118-1123. PMID: 11158604 [Pubmed Abstract]