Available Strain Details

Strain Information
Common Strain Name: Brca2 floxed Pricing and Ordering Information
Strain Nomenclature: STOCK Brca2tm1Brn/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): C2

Strain Description: This strain carries a conditional mutation in the endogenous Brca2 gene. LoxP sites were inserted into introns surrounding exon 11 in the Brca2 locus. Mice carrying the floxed allele have normal development and life span. Removal of the region flanked by the LoxP sites results in mice with the same phenotype as as mice with a conventional Brca2-null mutation - heterozygotes are normal and homozygotes fail to develop.
Mutation Information
Mutation Type: Targeted
Gene Name: Breast cancer 2
Gene Symbol: Brca2
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: STOCK
Approx. Generation: Homo
Organ Site: Breast
Additional Information
Cryopreservation Mating Scheme: EMBRYOS: The cryopreservation mating scheme is homozygous males x C57BL/6 (albino) females. When maintained as a live colony, breeder pairs were distributed as homozygotes. SPERM: NOT AVAILABLE FOR THIS STRAIN
Genotyping Information: Protocol 1: Allele: Brca2<tm1Brn>
Donating Investigator: Dr. Anton Berns

Key Reference: Jonkers J, Meuwissen R, van der Gulden H, Peterse H, van der Valk M, Berns A. 2001 Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet. 29:418-25. PMID: 11694875 [Pubmed Abstract]