Available Strain Details

Strain Information
Common Strain Name: IDH2 R140Q Pricing and Ordering Information
Strain Nomenclature: C57BL/6-Col1a1tm2(tetO-IDH2*R140Q)Ppp/NCI
Animal State: Frozen Embryo
Release Category (Required for MTA form): B3,C1

Strain Description: Expansion of hematopoietic stem/progenitor cells in the bone marrow and extramedullary hematopoiesis when crossed to M2-rtTA mice (further details can be found in Kats et al., 2014)
Mutation Information
Mutation Type: Targeted
Gene Name: isocitrate dehydrogenase
Gene Symbol: IDH2
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: C57BL/6
Approx. Generation:
Organ Site:
Additional Information
Cryopreservation Mating Scheme: The cryopreservation scheme is heterozygous males x C57BL/6 wildtype females. Average litter size is 4-8.
Genotyping Information: Protocol 1: Allele: Colla1<tm2(tetO-IDH2*R140QPpp>
Donating Investigator: Dr. Pier Paolo Pandolfi

Key Reference: Cell Stem Cell. 2014 Mar 6;14(3):329-41. doi: 10.1016/j.stem.2013.12.016. Epub 2014 Jan 16. Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance. Kats LM1, Reschke M1, Taulli R1, Pozdnyakova O2, Burgess K1, Bhargava P1, Straley K3, Karnik R4, Meissner A4, Small D5, Su SM3, Yen K3, Zhang J6, Pandolfi PP7. PMID 24440599 [Pubmed Abstract]