The Radiochemistry Support Group develops radiochemical methods to produce radiotracers for in vivo imaging in HIV studies, and chemical and biochemical methods to synthesize, identify, and characterize the radiolabeled antibody, cytokine, and small molecular probes.
We develop radiotracers to support noninvasive, in-vivo whole-body imaging in healthy and SIV/SHIV-infected nonhuman primates. The group uses single photon emission-computed tomography or positron emission tomography, nuclear imaging techniques that use radioactive substances injected into animals to provide images of the body.
We target antibodies, cytokines, or peptides by radiolabeling them with gamma emitters or positron emitters through appropriate chelating agents. The group also performs biochemical and radiochemical analysis and pharmacokinetic studies, including:
analysis of the radiotracers and their metabolites in the biological specimens after administration
in vivo and in vitro stability tests
in vitro immunogenicity test
ex vivo autoradiography
Our work supports the AIDS Imaging Research Section in the Division of Clinical Research at the National Institute of Allergy and Infectious Diseases.