The HLA Immunogenetics section studies the influence of immunogenetic variation on risk of human disease, outcome to therapeutic treatment, and vaccination. These studies include elucidation of the functional basis for the genetic associations identified.
The human leukocyte antigen (HLA) class I and class II genetic loci are the main subjects of our research. Apart from HLA genetic variation, there are other mechanisms by which HLA influences the immune response. These include:
- HLA class I interactions with innate immune receptors such as KIR and LILR
- Cell surface expression levels of HLA class I and class II
- Allele-specific variation in HLA dependency on tapasin, a key component involved in loading of antigenic peptides.
We are also developing innovative approaches to analyze gene-disease associations by combining experimental and computational methods.