HIV plays a direct role in causing blood cell cancers in rare instances, says a new study of HIV and tumor DNA.…

The spike protein critical for coronavirus research -- and for some COVID-19 vaccines -- slowly…

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New directorate expands serology capabilities

Vaccine, Immunity, and Cancer DirectoratePosted 2/23/2021
As the Frederick National Laboratory for Cancer Research (FNL) expands its serology efforts in response to the COVID-19 pandemic, the biomedical research institution formed a new section dedicated to those efforts and the evaluation and standardization of immune responses to vaccines, infections and cancer.

Establishment of the Vaccine, Immunity, and Cancer…

February Biotech Connector highlights progress in liquid biopsies

Partnership Development Office, Molecular Characterization LaboratoryPosted 2/9/2021
On February 25, the Biotech Connector series will highlight exciting research on liquid biopsies with two talks by local investigators. Liquid biopsies are highly sensitive blood tests that can detect fragments of tumor DNA, also known as circulating tumor DNA (ctDNA), in the blood—providing critical information about the tumor without an invasive tumor biopsy.

RAS Initiative reveals cancer-causing protein’s primary membrane orientation

RAS InitiativePosted 2/8/2021
RAS proteins reside on the inner cell membrane, where they use a lure like a fly fisherman to bring partner proteins to the membrane, leading to cell growth. Researchers at the Frederick National Laboratory for Cancer Research (FNL) used multiple experimental techniques along with a computer simulation to understand how KRAS functions at the inner side of the cell membrane and…

Frederick National Laboratory helps meet pressing need for accurate coronavirus antibody testing

Protein Expression LaboratoryPosted 2/3/2021
The Frederick National Laboratory (FNL) is providing scientists across the country with a key antigen used in antibody tests for the coronavirus after finding that the antigen is exceptionally sensitive and can be made rapidly and at low cost. This helps meet a pressing need for accurate testing.

3D model of SARS-CoV-2 created at the MRC…

Antibody manufactured at Frederick National Laboratory receives FDA approval to treat Ebola virus disease

Vaccine Clinical Materials ProgramPosted 2/2/2021
The Food and Drug Administration has approved a monoclonal antibody developed at the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, for the treatment of Ebola virus in adults and children. The approval was granted in late December.

The antibody, called…

Frederick National Laboratory triples CAR T cell manufacturing capacity for cancer clinical trials

Biopharmaceutical Development ProgramPosted 1/21/2021
The Frederick National Laboratory (FNL) has begun building out new production space that will triple its capacity to manufacture cell and gene therapies to support cancer clinical trials.

BDP manufacturing staff use a Miltenyi Prodigy for CAR T-cell production. Incubators seen in the background are available for non-Prodigy based cell therapy…

Frederick National Laboratory and Georgetown University present scientific lecture series in 2021

Posted 1/12/2021
The Frederick National Laboratory for Cancer Research and Georgetown University will present the second annual Scientific Partners Distinguished Lecture Series featuring five seminars by leading scientists from both organizations. The 2021 series is open to the public and will be completely virtual. Participation details for each seminar will be announced prior to the event.…

Clones complicate a cure and pose problems for people with HIV

AIDS and Cancer Virus ProgramPosted 12/21/2020
A new advance in our understanding of HIV comes from what Steve Hughes, Ph.D., calls “an odd observation.”

Certain people living with HIV had only partially suppressed levels of virus in their blood despite being on effective antiretroviral therapy (drugs used to manage HIV). At first, an explanation seemed like it would be simple—but it wasn’t.

Coronavirus protein ‘shakes off’ some antibodies by changing shape

Posted 12/15/2020
A new study suggests that part of the SARS-CoV-2 virus shifts its shape based on its surroundings, throwing off potentially protective antibodies that might prevent it from causing COVID-19.

The shapeshifting rids the coronavirus of certain antibodies that attach to it, say the study’s authors, who are based at the Vaccine Research Center of the National…

FNL’s capstone partnership with Georgetown provides student training opportunity

Posted 12/6/2020
As a national laboratory, the Frederick National Laboratory for Cancer Research (FNL) is committed to supporting the next generation of biomedical researchers—a generation for which data science skills are becoming increasingly critical.

Mark Jensen, Ph.D.

Fuyuan Wang

To that end, the FNL signed a…

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