Posted 3/25/2024
Scientists and clinicians whose discoveries have shaped the understanding of HIV disease will provide updates on the...
Posted 2/22/2024
There are many paths for women to travel to find success in science. That was a crucial theme conveyed by the four...
Posted 2/7/2024
Frederick National Laboratory researchers identified a vitamin A derivative (retinoid) that when combined with a...
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Analyzing tumors of cancer patients with robust response to treatment may offer clues on how others can benefit and improve tailored treatment
Posted 6/7/2020Patients who have a better-than-average response to cancer treatment can help further research that might benefit all cancer patients. Analysis of their tumor tissues can provide clues about the genetic keys that make their tumor more responsive to treatment.
Fig 1. Tumor tissue from a patient with Uterine Corpus Endometrial Carcinoma (UCEC) was fixed in formalin and…
Malian Prime Minister visits CMRPD-supported University Clinical Research Center pivoting to COVID-19 research
Posted 6/4/2020As word of the SARS-CoV-2 outbreak spread around the world, countries began looking inward to prepare. In Mali, Prime Minister Dr. Boubou Cisse visited University Clinical Research Center (UCRC) laboratories at the University of Sciences, Techniques, and Technologies of Bamako (USTTB) in March to see how its facilities could help.
UCRC provides facilities and technology…
New England Journal of Medicine paper shows remdesivir speeds recovery for Hospitalized COVID-19 patients
Clinical Monitoring Research ProgramPosted 6/3/2020The antiviral treatment remdesivir accelerated recovery time among hospitalized participants with advanced COVID-19 compared to participants who received placebo containing inactive ingredients, according to results of a clinical trial published May 22 in the New England Journal of Medicine.
The median time to recovery was 11 days for participants who received remdesivir…
Collaboration with the London School of Hygiene & Tropical Medicine investigates a single-dose HPV vaccine in Tanzania
Posted 6/1/2020Is a single dose of a human papillomavirus (HPV) vaccine sufficient to induce an immune response capable of preventing HPV infection and cervical cancer? That is an area of focus of the Frederick National Laboratory’s HPV Serology Laboratory, this time with a new collaboration with the London School of Hygiene & Tropical Medicine School to investigate immune responses…
FNL supports website development for official COVID-19 treatment guidelines
Posted 5/28/2020As COVID-19 spread around the U.S., health care providers needed guidelines to treat patients—and they needed them fast.
The solution? A website that would house data- and expert-backed clinical treatment guidelines devised by a panel of U.S. physicians, statisticians, and other experts from the National Institutes of Health (NIH), universities, and health care…
Ebola clinical trial supported by FNL receives “Trial of the Year” award
Posted 5/26/2020The Pamoja Tulinde Maisha (PALM, Kiswahili for “together save lives”) trial, a large Ebola research effort supported by the Frederick National Laboratory, has received the David Sackett Trial of the Year Award for 2019.
Ian Crozier, M.D., Frederick National Laboratory/NIAID, administers supportive care and an experimental treatment to a patient in one of the Ebola…
Study on “rapid autopsy” tumor tissue as a valuable research tool is among abstracts presented at 2020 ASCO Virtual Scientific Program
Posted 5/25/2020Tissue obtained from tumors during an autopsy conducted shortly after a cancer patient’s death provides unique insights into how the tumors evolved, spread and resisted treatment. The Frederick National Laboratory’s Molecular Characterization Laboratory reports on results of a study on preclinical models established from “rapid autopsy” tumors during the 2020 American Society…
The Frederick National Laboratory for Cancer Research and COVID-19 serology testing
Vaccine, Immunity, and Cancer DirectoratePosted 5/5/2020In its urgent efforts to confront the novel coronavirus, the U.S. Food and Drug Administration (FDA) has tapped the Frederick National Laboratory for Cancer Research (FNL) to scientifically inform its decision-making on potential approval of blood tests for the presence of antibodies to SARS-CoV-2.
FNL has an adaptive cancer research infrastructure and longstanding…
FNL Team Places Among Top Three in International Computing Contest
Posted 5/3/2020Three employees from Frederick National Laboratory’s Imaging and Visualization Group recently claimed a top spot of a computing and artificial intelligence challenge that attracted 170 competing groups from around the world.
The team—Yanling Liu, Ph.D.; Hyun Jung, Ph.D.; and G. Tom Brown, M.D., Ph.D.—took third place overall and was the top group in the “Industry” category…
FNL RAS Investigators Take Published KRAS Study a Step Further, Share Findings in PNAS Letter to Editor
Posted 4/27/2020A scientific paper on a member of the RAS family of oncogenes published last summer so intrigued Frederick National Laboratory computational scientist Trent Balius that he and his and colleagues performed a follow-up study, shedding more light on the topic.
Balius and FNL colleagues in the National Cancer Institute’s RAS Initiative shared their findings as a letter to the…
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