Program
The Retrovirus-Cell Interaction Section uses in vitro and in vivo approaches to define both the potential and the limitations of cellular immune control of AIDS virus infection.
We focus on studies in nonhuman primate (NHP) models, using lymphocyte engineering approaches to study and optimize the ability of cellular immune responses to…
The Retrovirus-Cell Interaction Section uses both in vitro and in vivo studies to define the characteristics and potential of cellular immune control of AIDS virus infection. Our researchers study the interactions between AIDS viruses and their host cells, focusing on SIV and rhesus macaque T cell systems. We apply cellular engineering to optimize…
Program
The Retroviral Pathogenesis Section conducts basic, applied, and translational research to understand retroviral disease mechanisms. We work with nonhuman primate (NHP) models, employing in vitro and in vivo approaches, and evaluate strategies to more effectively prevent and treat AIDS virus infections and their consequences.
Our basic studies…
The Retroviral Pathogenesis Section conducts both in vitro and in vivo research to improve the basic understanding of AIDS virus pathogenesis through applied and basic studies. Applied studies evaluate candidate vaccines and other prevention approaches, along with studies of novel drug and immunotherapeutic interventions to target virus that…
Program
We use molecular biology approaches to develop and employ novel viral systems to leverage the advantages of nonhuman primate models. Our work addresses critical questions in key areas of AIDS research, including transmission, adaptation, persistence, and evolution that allows the pathogen to evade eradication/cure strategies.
Arresting the…
The Retroviral Evolution Section conducts groundbreaking research to better understand fundamental features of HIV transmission, persistence, and evolution that allow the pathogen to continue evading eradication strategies.
Our scientists harness molecular biology approaches to generate, manipulate, and employ novel viral systems to take full…
Program
The Quantitative Molecular Diagnostics Core develops and applies assays to measure levels of AIDS virus nucleic acids and related analytes in specimens from nonhuman primate (NHP) studies.
We provide quantitative molecular analyses for laboratories within the AIDS and Cancer Virus Program, the National Institutes of Health, and the extramural…
The Quantitative Molecular Diagnostics Core provides quantitative molecular analyses for laboratories within the AIDS and Cancer Virus Program, National Institutes of Health, and external research community.
The core performs testing for SIV and related viruses, with a focus on determining viral RNA and viral DNA levels in specimens derived from…
Program
The Nonhuman Primate Research Support Core provides critical logistical and laboratory support and coordination for all internal nonhuman primate (NHP) studies.
Our team schedules all animal-study events and prepares drugs for administration to study animals for all NHP studies conducted by scientists in the AIDS and Cancer Virus Program and…
The Nonhuman Primate Research Support Core provides ongoing research support for HIV/AIDS vaccine, pathogenesis, and treatment studies conducted by the AIDS and Cancer Virus Research Program scientists and their collaborators.
The core receives, processes, distributes, and stores specimens of nonhuman primate blood, tissues, and other bodily…
Program
The HIV Molecular Monitoring Core provides HIV-1 ultrasensitive viral load and sequencing services. In conjunction with the AIDS and Cancer Virus Program Viral Evolution Core, our services are available for studies and research projects from scientists within the National Institutes of Health and the external HIV research community.
The HIV…
The HIV Molecular Monitoring Core provides HIV molecular quantification and sequence analysis for studies and research projects from scientists within the National Institutes of Health and the external research community.
The core works closely with the National Cancer Institute’s HIV Dynamics and Replication Program to coordinate research and…
Program
The Cellular Immunity Core provides comprehensive flow cytometry, cell sorting, and cellular immune analysis support for the AIDS and Cancer Virus Program and for collaborative preclinical research studies and basic and translational research projects, using cutting-edge instrumentation, methods, and analysis software. Additionally, the core…
The Cellular Immunity Core provides comprehensive flow cytometry, cell sorting, and cellular immune analysis support to internal investigators and collaborators for nonhuman primate studies using advanced flow cytometry methods, instrumentation, and software.
Program
We provide the HIV/AIDS research community with distinct biological research products not readily available from other sources.
The Biological Products Core makes these products available to Frederick National Laboratory for Cancer Research, intramural, and extramural investigators at no cost. Extramural laboratories must establish a Material…
We provide the AIDS research community with access to biological research products, most of which are unique and not available from other sources. These are obtained at no cost by extramural laboratories through a material transfer agreement between the requesting institution and the National Cancer Institute.
These research products include:…
Program
The AIDS and Cancer Virus Program investigates ways to diagnose, prevent, and treat HIV infection and AIDS-related tumors associated with cancer viruses, such as Kaposi sarcoma–associated herpesvirus. We have principal investigator-headed research sections and research support cores that provide innovative, often unique, capabilities in support of…
The AIDS and Cancer Virus Program works to improve the prevention, diagnosis, and treatment of HIV infection and AIDS-related tumors through basic, applied, and translational research, including development and sharing of novel experimental models, reagents and analytical methods.
Through investigator-driven research and extensive collaborations…
News
While a unique AIDS vaccine approach had previously shown an encouraging and unprecedented kind of protection against AIDS virus infection in nonhuman primate models, the underlying mechanism for this distinctive form of vaccine protection has remained unclear – until now. New research has provided important insights into understanding how the…
