Validated CRISPR-associated protein and gRNA Reagents for NGCMs

Person of Contact Kendra Schwieso (
Proposal Due Date Wednesday, May 18, 2022 (Closed 2 years ago)
NAICS Codes 541714, 541715
  • Research Category Research & Development Services & Subcontracts
  • Solicitation Number S22-027
  • NCI OA Contract Number 75N91019D00024 – NCI-FFRDC


To contribute towards the goals of the Human Cancer Model Initiative (HCMI), the scope of this solicitation is to generate and deliver to the research community, optimized and validated human CRISPR gene modification reagents for all transcribed genes for the purpose of whole genome screening in Next Generation Cancer Models (NGCMs). Reagents and protocols shall be developed and optimized for use in multiple NGCMs (across different model types such as organoids, neurosphere, conditionally reprogrammed cells, etc., and across different cancers), and shared with the community, along with quality parameters and data demonstrating efficacy of the developed CRISPR reagent.

Proposal Instructions

Solicitation questions will be due by 1:00pm ET on Wednesday, April 13, 2022. A pre-proposal teleconference will be held at 3:00pm ET on Thursday, April 28, 2022. To receive the full solicitation package please contact Kendra Schwieso.