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      HIV/SIV research

      Researchers identify lower GI tract tissues as source of initial rebound of HIV-like virus after stopping ART

      A new study used an innovative method to track anatomic origin of rebound of HIV-like virus.
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      Analysis of paired blood biopsies, tumor tissue as biomarkers for cancer to be presented at ASCO

      FNL scientists will present a recent study comparing mutations found in paired tuors and ctDNA at the 2026 American Society for Clinical Oncology Annual Meeting.
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    Our researchers publish hundreds of papers each year in various peer-reviewed journals, including Science, Nature, and The New England Journal of Medicine.
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      Save the date Oct 7-9, 2026

      6th RAS Initiative Symposium

      Join us for the 2026 RAS Initiative Symposium.
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      Importance of innovation Within FNL, innovation plays a pivotal role in delivering new and enhanced technologies that empower us to tackle essential scientific inquiries, enhance our services, and ultimately contribute to the wellbeing of patients.
      Vladimir Popov, Ph.D., MBA
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      Life Sciences Symposium Jun 16-18, 2026

      Reproducibility in Science 2026

      Join us for a symposium focused on reproducibility in biomedical research.
    American Association for Cancer Research Annual Meeting

    Preclinical data on potential treatment for RAS-driven cancers to be presented at AACR26

    Studies on BBO-10203 and BBO-11818 will be presented in San Diego.
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      Barcode Analysis Tool

      Download files to demultiplex next-generation sequencing and determine the abundance of individually barcoded SIV/SHIV viral lineages.
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      Next deadline to apply: Sept. 1, 2026

      Preclinical characterization of nanoparticles to facilitate the regulatory review of nanotechnology concepts intended as cancer therapies and diagnostics.
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        • An in vitro drug release study in human plasma
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      Did you know?
      We are home to unique scientific expertise and technological capabilities available nowhere else. The Technical Services Program through the Partnership Development Office makes some of these capabilities and services readily available to the external research community at-cost to advance biomedical research around the world.
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      Collection of scientific groups at FNL working to develop, deposit and share standards and references in biological research.
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    Learn about challenges in clinical research during emergency infectious disease outbreaks and strategies to overcome them.
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      Analysis of paired blood biopsies, tumor tissue as biomarkers for cancer to be presented at ASCO

      FNL scientists will present a recent study comparing mutations found in paired tuors and ctDNA at the 2026 American Society for Clinical Oncology Annual Meeting.
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      Technologies invented and patented by researchers at the Frederick National Laboratory
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      Commercial Service
      Due in 2 weeks 6 days (07/01/2026)
      Commercial Goods/Services
      X27-101
    Vendor Webinar Jul 9, 2026

    Q2 How to Do Business with Leidos Biomedical Research

    This session will provide a roadmap for navigating the procurement process.
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    Brilliant teamwork The team here is made up of brilliant scientists. Coming from a diverse research background myself, it’s inspiring to be in a room where everyone contributes something unique. I feel truly privileged to be part of it.
    Samarth Mathur, Ph.D.
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    Did you know?
    About 30% of all human cancers are driven by mutations of the RAS family of genes. The RAS Initiative endeavors to better understand the RAS oncogene and discover its vulnerabilities to treat RAS-related cancers.

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  • Research & Technology
    • Science Areas
      • AIDS and Cancer Virus Program
        • Sections
          • Retroviral Evolution Section
          • Retroviral Pathogenesis Section
          • Retrovirus-Cell Interaction Section
          • Viral Oncology Section
          • Viral Persistence Section
        • Cores
          • Biological Products Core
          • Cellular Immunity Core
          • HIV Molecular Monitoring Core
          • Nonhuman Primate Research Support Core
          • Quantitative Molecular Diagnostics Core
          • Tissue Analysis and Retroviral Protein Chemistry Core
          • Viral Evolution Core
      • Basic Science Program
        • Experimental Structural Biology Section
        • Biophysics and Computational Biology Section
        • Epigenetics Section
        • HLA Immunogenetics Section
        • Molecular Immunology Section
      • Bioinformatics and Computational Science
        • Advanced Biomedical Computational Science
        • Center for Technical Operations Support
      • Cancer Research Technology Program
        • Advanced Cryo-Electron Microscopy Technology Group
        • Antibody Characterization Laboratory
        • CLIA Molecular Diagnostics Laboratory
        • Imaging Mass Cytometry Laboratory
        • Protein Expression Laboratory
      • Laboratory Animal Sciences Program
        • Animal Diagnostics Laboratory
        • Animal Research Technical Support
        • Genome Modification Core
        • Gnotobiotics Facility
        • Laboratory Animal Medicine
        • Molecular Histopathology Laboratory
        • Mouse Modeling and Cryopreservation
        • Small Animal Imaging Program
      • Vaccine, Immunity, and Cancer Directorate
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    • Clinical Trial Support
      • Applied and Developmental Research Directorate
        • Clinical Services Program
          • AIDS Monitoring Laboratory
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          • Flow Cytometry Support Laboratory
          • Immunological Monitoring Laboratory
          • Laboratory of Human Retrovirology and Immunoinformatics
          • Laboratory of Molecular Cell Biology
          • Neutrophil Monitoring Laboratory
          • Radiochemistry Program
          • Virus Isolation and Serology Laboratory
        • DCTD Support
          • Cancer Imaging Informatics Laboratory
          • Clinical Pharmacodynamics - Biomarkers Program
          • In Vitro Evaluation and Molecular Pharmacology Laboratories
          • In Vivo Evaluation Program
          • Investigative Toxicology Laboratory
          • NExT Chemical Biology Consortium Support Programs
          • Natural Products Support Group
          • Pharmacokinetics and Drug Analysis Group
          • Radiochemistry Support Group
      • Biopharmaceutical Development Program
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  • Innovation & Initiatives
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    • Data & Repositories
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    • National Scientific User Facilities
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    • Training & Education
      • cGMP Training
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      • Project Management Night Out Seminar Series
    • Technical Services
      • Program Overview
      • HIV/SIV Services
        • Cellular or Tissue SIV/SHIV RNA and DNA testing
        • HIV/SIV Single Genome Amplification and Sequencing
        • Lineage-specific Next Gen Multiplex In Situ Hybridization for HIV or SIV RNA and DNA
        • Next-generation sequencing analysis of barcoded SIV, SHIV, or HIV
        • Novel CD4+ T Cell Specific Immunohistochemistry Detection and Analysis
        • Plasma or CSF SIV/SHIV RNA measurements
        • Quantitative Assessment of Lymphoid Tissue Fibrosis
        • Quantitative assessment of HIV or SIV viral DNA in laser capture microdissected immune cells
        • Viral Integration Site Analysis (VISA) for HIV studies
      • Nanomedicine & Nanoformulation
        • An in vitro drug release study in human plasma
        • Pharmacokinetic study of nanomedicine in rats
      • Other
        • Detection of Mycobacterium tuberculosis DNA
        • TypeSeq2 HPV genotyping services
    • Universal Standards & Reference Materials
      • AI and Data Science
      • Antibody Science
      • Biospecimen Assays
      • Biopharmaceutical Development
      • Electron Microscopy
      • Serology Operating Procedures
      • Human SARS-CoV-2 Serology Standard
      • Nanotechnology
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