Content tagged as

Molecular Biology

The Protein Expression Laboratory generates DNA, cell line, and protein reagents for biomedical research from basic science to drug discovery. The team uses cutting-edge protein production technologies to generate proteins using bacteria, insect cells, or mammalian cells at scales from micrograms to grams. Quality control is a major emphasis of…
The spike protein critical for coronavirus research -- and for some COVID-19 vaccines -- slowly deteriorates while in storage, which can affect research results and vaccine production, a new study suggests. But the effect can be reversed. The SARS-CoV-2 spike protein, which is used in laboratories around the world, is unstable under…
A team of scientists has gone fishing, but they’re interested in more than the bounty of the seas: They’ve also cast out nets on land. And they’ve never left the laboratory. Their “nets” are high-powered chemical and biological analyses. The team, a group of cancer biologists, dermatologists, biochemists, natural product chemists, and…
In a recent study that sought to measure antibody prevalence in participants who had not previously been diagnosed with a SARS-CoV-2 infection, a team of National Institutes of Health researchers reported that for every person diagnosed with COVID-19 in the spring and summer of 2020, it’s estimated that five additional people infected with the…
The Computational Structural Biology Section draws on multidisciplinary advances to decipher the mechanisms and pharmacology of oncogenic proteins and their signaling at the detailed molecular level.   Our work is based on the concept of the free energy landscape. The landscape describes protein molecules as consisting of ensembles of…
The Basic Science Program conducts independent research in basic and applied molecular biology, immunology, retrovirology, cancer biology, and human genetics.  Our goal is to understand biological processes related to cancer and other diseases and to develop cutting-edge tools to accelerate scientific progress.  The program’s areas of focus…
The Neutrophil Monitoring Laboratory performs testing to assess neutrophil dysfunction in patients with various primary immunodeficiencies.  We develop state-of-the-art assays to evaluate a variety of neutrophil functions such as reactive oxygen species production, chemotaxis, cell shape change and spreading, exocytosis, and alterations in…
The Laboratory of Molecular Cell Biology conducts research in collaboration with scientists at the National Institute of Allergy and Infectious Diseases to understand the biology of T cell activation and HIV persistence.  We support the Laboratory of Immunoregulation by developing and performing quantitative and qualitative polymerase chain…
The Antibody Characterization Laboratory is a reference program that develops antibodies to be made available to the scientific community, including extensive antibody-characterization data and protocols. The laboratory uses an array of techniques to determine the properties of antibodies and other renewable reagents that can be used in cancer-…
Overview Purified recombinant proteins are an essential resource for scientists in any stage of research. High-quality proteins ensure that downstream science produces accurate and reproducible results. This is particularly critical for protein reagents used in drug discovery and structural biology. The use of standardized methods for…