Content tagged as

Molecular Biology

The Computational Structural Biology Section draws on multidisciplinary advances to decipher the mechanisms and pharmacology of oncogenic proteins and their signaling at the detailed molecular level.   Our work is based on the concept of the free energy landscape. The landscape describes protein molecules as consisting of ensembles of…
The Basic Science Program conducts independent research in basic and applied molecular biology, immunology, retrovirology, cancer biology, and human genetics.  Our goal is to understand biological processes related to cancer and other diseases and to develop cutting-edge tools to accelerate scientific progress.  The program’s areas of focus…
The Neutrophil Monitoring Laboratory performs testing to assess neutrophil dysfunction in patients with various primary immunodeficiencies.  We develop state-of-the-art assays to evaluate a variety of neutrophil functions such as reactive oxygen species production, chemotaxis, cell shape change and spreading, exocytosis, and alterations in…
The Laboratory of Molecular Cell Biology conducts research in collaboration with scientists at the National Institute of Allergy and Infectious Diseases to understand the biology of T cell activation and HIV persistence.  We support the Laboratory of Immunoregulation by developing and performing quantitative and qualitative polymerase chain…
The Antibody Characterization Laboratory is a reference program that develops antibodies to be made available to the scientific community, including extensive antibody-characterization data and protocols. The laboratory uses an array of techniques to determine the properties of antibodies and other renewable reagents that can be used in cancer-…
Overview Purified recombinant proteins are an essential resource for scientists in any stage of research. High-quality proteins ensure that downstream science produces accurate and reproducible results. This is particularly critical for protein reagents used in drug discovery and structural biology. The use of standardized methods for…
Overview Nondiagnostic clinical assays quantify drug mechanisms and responses in human clinical trials, including predicted biomarkers of safety and efficacy, as well as mechanistic markers of pharmacodynamics and toxicodynamics. These biospecimen assays are used to support key decisions during drug development. The integrity of these…
The Molecular Characterization Laboratory is a clinical and research laboratory that performs genomic sequencing in support of clinical and pre-clinical studies sponsored by the National Cancer Institute’s Division of Cancer Treatment and Diagnosis.  We have a research laboratory and CLIA-certified laboratories to support clinical testing.  We…
The Frederick National Laboratory (FNL) is providing scientists across the country with a key antigen used in antibody tests for the coronavirus after finding that the antigen is exceptionally sensitive and can be made rapidly and at low cost. This helps meet a pressing need for accurate testing. 3D model of SARS-CoV-2 created at the MRC…
A team led by Frank McCormick, Ph.D., FRS, D.Sc. (Hon), RAS National Program Advisor at the Frederick National Laboratory for Cancer Research and professor emeritus at UCSF Helen Diller Family Comprehensive Cancer Center, has found a new vulnerability in pancreatic cancer and revealed a potential strategy for combating one of the most treatment-…