News
The first conference held under the auspices of Frederick National Laboratory’s (FNL’s) Scientific Standards Hub, an initiative formed to address the scientific reproducibility crisis, has just wrapped up.
The two-day event, dubbed The α-Twists and β-Turns of Recombinant Protein Production, examined standardization in laboratory and commercial…
News
Each year, the Frederick National Laboratory offers its scientists an opportunity to compete for funding to conduct the research they view as critical to advance biomedical research but is outside the scope of their daily research activities.
This year, three proposals earned funding through the program, known as the Laboratory Directed…
News
Severe forms of neurofibromatosis linked to disruptions in a protein partnership
New research by Frederick National Laboratory (FNL) researchers and their colleagues takes an important step toward explaining complex mutations in a gene called NF1 that is known to cause a disorder known as neurofibromatosis type 1. The study also has potential…
News
Upon hearing earlier this year that she was elected to the prestigious American Academy of Arts and Sciences, cancer scientist Mary Carrington wished she could share the news with her beloved late father-in-law, a former law school dean at Duke.
She had only discovered Paul Carrington’s academy membership after he died last year, when she and…
News
The success of today’s COVID-19 vaccines has given medical nanotechnology a long-awaited boost, with a renewed interest in its potential for treating disease among big pharma and small start-ups.
Over the years, nanotechnology has had its ups and downs in the public eye, cycling from peaks of excitement and fanfare–and a little too much hype–…
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The classical RAS family of proteins functions as molecular switches at the cell’s plasma membrane where it cycles between an active and inactive state. The active state initiates a cascade of events that promote downstream signaling to regulate cellular functions, such as cell proliferation.
Mutations and dysregulation of the RAS-RAF-MEK-ERK…
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The Nanotechnology Characterization Laboratory is working with industry partners to bolster the use of nanotechnology in drug development and delivery as the interest in the promising technology expands.
“Pharma has initially been hesitant to get into nano because it’s too much risk versus reward,” said Jeffrey D. Clogston, Ph.D., the…
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Predicting disease severity from a SARS-CoV-2 infection has been an elusive but critical need in addressing the COVID-19 pandemic, as some patients experience mild symptoms while others develop fatal complications. As scientists try to determine what contributes to infection levels and mortality, several medical signs are providing potential…
Program
The Protein Expression Laboratory generates DNA, cell line, and protein reagents for biomedical research from basic science to drug discovery. The team uses cutting-edge protein production technologies to generate proteins using bacteria, insect cells, or mammalian cells at scales from micrograms to grams.
Quality control is a major emphasis…
The Protein Expression Laboratory generates DNA, cell line, and protein reagents for biomedical research from basic science to drug discovery. The team uses cutting-edge protein production technologies to generate proteins using bacteria, insect cells, or mammalian cells at scales from micrograms to grams. Quality control is a major emphasis of…
News
The spike protein critical for coronavirus research -- and for some COVID-19 vaccines -- slowly deteriorates while in storage, which can affect research results and vaccine production, a new study suggests. But the effect can be reversed.
The SARS-CoV-2 spike protein, which is used in laboratories around the world, is unstable under…
