Program
The Laboratory of Human Retrovirology and Immunoinformatics conducts basic and clinical research to better understand the immunopathological effects of infectious diseases and how those effects are influenced by genetics.
Basic and translational research group
We support and collaborate with National Institute of Allergy and Infectious…
The Laboratory of Human Retrovirology and Immunoinformatics performs basic, clinical, and bioinformatic research to gain a better understanding of the immunopathological effects of HIV and HIV-related infectious diseases and how they’re influenced by genetics. We support and collaborate with the National Institute of Allergy and Infectious…
Program
The Immunological Monitoring Laboratory monitors clinical trials of viral diseases, processes clinical specimens, and analyzes immune system responses. Our scientists perform cytokine analyses, determine viral loads, and quantify antigen-specific antibody levels in plasma from patients and nonhuman primates with bacterial and viral diseases.…
The Immunological Monitoring Laboratory monitors clinical trials of viral diseases, processes clinical specimens, and analyzes immune system responses.
The laboratory processes and archives blood products from patients enrolled in numerous ongoing clinical trials at the National Institutes of Health Clinical Center. This extensive archive…
Program
The Clinical Support Laboratory processes and works with samples from clinical trials at the National Cancer Institute and tests samples, with an emphasis on the immune system’s function. We work with principal investigators to study the status of the immune system in clinical trial participants or nonhuman primates who get treated with anticancer…
The Clinical Support Laboratory provides clinical trial processing support to the National Cancer Institute and performs sample testing with an emphasis on immune function.
We work with National Cancer Institute investigators on immune status of clinical trial subjects treated with anti-cancer immune modulators.
The laboratory provides…
Program
The Viral Persistence Section seeks to better understand the establishment, maintenance, and consequences of persistent AIDS virus infections.
To achieve these goals, we employ existing and novel nonhuman primate (NHP) models of HIV infection and our extensive experience in the administration and evaluation of antiretroviral agents in NHPs.…
The Viral Persistence Section studies the establishment, spread, and maintenance of persistent AIDS virus infections and persistent opportunistic viral infections that cause cancer in the setting of AIDS.
The laboratory uses a combination of nonhuman primate models of HIV infection, along with advanced cell culture, virology, and molecular…
Program
The Viral Oncology Section studies the epidemiology, immune response, and genetics of Kaposi sarcoma–associated herpesvirus (KSHV). Our work extends to related oncogenic viruses and associated malignancies.
Understanding the role of viruses in cancer
Seven viruses are known to cause about 20% of human cancers. Our studies are primarily…
The Viral Oncology Section studies the role of viruses in cancer, focusing primarily on Kaposi’s sarcoma–associated herpesvirus (KSHV) and related malignancies. Our research encompasses epidemiology, molecular virology, immunology, and translational studies.
Program
The Retrovirus-Cell Interaction Section uses in vitro and in vivo approaches to define both the potential and the limitations of cellular immune control of AIDS virus infection.
We focus on studies in nonhuman primate (NHP) models, using lymphocyte engineering approaches to study and optimize the ability of cellular immune responses to…
The Retrovirus-Cell Interaction Section uses both in vitro and in vivo studies to define the characteristics and potential of cellular immune control of AIDS virus infection. Our researchers study the interactions between AIDS viruses and their host cells, focusing on SIV and rhesus macaque T cell systems. We apply cellular engineering to optimize…
Program
The AIDS and Cancer Virus Program investigates ways to diagnose, prevent, and treat HIV infection and AIDS-related tumors associated with cancer viruses, such as Kaposi sarcoma–associated herpesvirus. We have principal investigator-headed research sections and research support cores that provide innovative, often unique, capabilities in support of…
The AIDS and Cancer Virus Program works to improve the prevention, diagnosis, and treatment of HIV infection and AIDS-related tumors through basic, applied, and translational research, including development and sharing of novel experimental models, reagents and analytical methods.
Through investigator-driven research and extensive collaborations…
Program
We provide comprehensive preclinical characterization of nanomedicine formulations. Our work encompasses physicochemical characterization as well as in vitro and in vivo immunological, pharmacological, and toxicological evaluations.
Exploring new strategies for nanotech drug development
The laboratory has characterized hundreds of…
The Nanotechnology Characterization Laboratory provides comprehensive preclinical characterization of nanomedicine formulations, encompassing physicochemical characterization as well as in vitro and in vivo immunology, pharmacology and toxicology evaluation.
The laboratory has characterized hundreds of unique nanomedicine formulations and has…
Program
The Antibody Characterization Laboratory is a reference program that develops antibodies for the scientific community, including extensive antibody characterization data and protocols.
The laboratory uses an array of techniques to determine the properties of antibodies and other renewable reagents that can be used in cancer-related research.…
The Antibody Characterization Laboratory is a reference program that develops antibodies to be made available to the scientific community, including extensive antibody-characterization data and protocols.
The laboratory uses an array of techniques to determine the properties of antibodies and other renewable reagents that can be used in cancer-…
Basic page
The use of nanotechnology has become common in the pharmaceutical industry due to the benefits that nanoparticles offer to drug delivery, vaccines, immunotherapies, and medical devices. The Nanotechnology Characterization Laboratory has characterized over 400 nanotechnology-based concepts, 17 of which advanced to clinical trials. Among those,…
