Content tagged as

Immunology

The Clinical and Translational Serology Task Force (CTTF) is one of the U.S. National Cancer Institute’s initiatives to respond to the SARS-CoV-2 pandemic. This is the first installment of its quarterly newsletter. The running publication will include updates about ongoing efforts, information about research, opportunities for communication and…
The National Cancer Institute–Frederick National Laboratory Clinical and Translational Serology Operations Team is coordinating the Collaborative Assay Harmonization Study. The effort seeks to improve scientists’ ability to compare data between SARS-CoV-2 studies and vaccines. Participating investigators are comparing the performance of…
Since its deployment in December 2020, the U.S. SARS-CoV-2 Serology Standard has been adopted by laboratories near and far. As of September 15, 2021, there had been 84 requests for the standard from the pharmaceutical industry, U.S. government researchers, the National Cancer Institute's Serological Sciences Network (SeroNet), academic…
Nearly 18 months into its existence, the SARS-CoV-2 serology assay evaluation program is still going strong. The program’s goal is to identify accurate assays while recognizing those with unacceptable performance. Frederick National Laboratory’s Serology Laboratory has tested more than 100 assays since the program began in April 2020. The…
The Food and Drug Administration granted an Emergency Use Authorization in August for immunocompromised individuals and in September for people aged 65 years and older to receive a third dose of an mRNA SARS-CoV-2 vaccine. Studies are ongoing, but data collected so far indicate that a third, additional dose for these populations would be…
SeroNews is the quarterly newsletter from the NCI Serological Sciences Network. Each edition includes clinical and translational serology highlights. This newsletter will be published every three to four months and is intended to summarize key priorities, perspectives, and events of a very engaged and enthusiastic team of scientists, clinicians…
Standardized serology assays, reagents, and procedures are critical to ensure data quality and allow comparison of results from different studies and vaccines. The Vaccine, Immunity, and Cancer Directorate’s Serology Laboratory launched two initiatives to address the need for standardization and harmonization of serological assays for anti-HPV…
The Molecular Immunology Section studies mechanisms of gene regulation, focusing on the innate immune system. The section is affiliated with, and provides expertise in gene regulation to the Laboratory of Cancer Immunometabolism of the National Cancer Institute Center for Cancer Research. 
The HLA Immunogenetics section studies the influence of immunogenetic variation on risk of human disease, outcome to therapeutic treatment, and vaccination.  These studies include elucidation of the functional basis for the genetic associations identified.  The human leukocyte antigen (HLA) class I and class II genetic loci are the main subjects …
The Basic Science Program conducts independent research in basic and applied molecular biology, immunology, retrovirology, cancer biology, and human genetics.  Our goal is to understand biological processes related to cancer and other diseases and to develop cutting-edge tools to accelerate scientific progress.  The program’s areas of focus…