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Cancer Research

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Is your billion-dollar oncology artificial intelligence (AI) cutting-edge technology, or is it artificial ignorance? That’s the question Frederick National Laboratory’s Maggie Scully, Ph.D., and a panel of industry experts seek to tackle at the BIO International Convention in Boston on June 7. Karim Budhwani, Ph.D., DLA, CEO-scientist of…
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Dogs and humans have been companions throughout recorded history. Our four-legged friends appear in early written tales, such as the Mesopotamian poem The Epic of Gilgamesh, and are mentioned by name in ancient Egyptian inscriptions. In prehistoric gravesites worldwide, dogs are found laid to rest alongside humans. They’ve been with us through…
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By training computer models to assess pathology images of rhabdomyosarcoma tumors, researchers hope to help doctors better tailor treatments to patients. Researchers at the Frederick National Laboratory for Cancer Research and the National Cancer Institute developed an artificial intelligence-based system that can anticipate the severity of…
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The Biopharmaceutical Development Program (BDP) at Frederick National Laboratory is engineering cells into cancer-killers that are being used to treat children and young adults participating in early-phase pediatric cancer trials. The treatment is called chimeric antigen receptor (CAR) T cell therapy. CAR T cells are a type of white blood cell…
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Common drugs for controlling pain and inflammation – such as aspirin and ibuprofen – improved overall lung cancer survival by a statistically significant margin in a long-term study of patient medical records. This finding called for more definitive randomized clinical trials. Use of non-steroidal anti-inflammatory drugs (NSAIDs) was…
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Five new projects led by Frederick National Laboratory for Cancer Research (FNL) scientists have earned Laboratory Directed Exploratory Research (LDER) funding for the upcoming fiscal year. The LDER program, which was modeled after the U.S. Department of Energy’s Laboratory Directed Research and Development program, provides FNL scientists…
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Some of the world’s top scientific leaders in the field will highlight the current progress of artificial intelligence (AI) applications in cancer research and clinical care at a scientific symposium hosted by Hood College in partnership with the Frederick National Laboratory for Cancer Research, September 2022. Cancer researchers are…
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On any given day, microscopist Susan Lea, D.Phil., and her team at NCI at Frederick collect more data than can fit on any standard hard drive, creating a challenge for data storage and analysis. Their average data collection is 5 terabytes, a quantity roughly 20 times the storage capacity of a 256-gigabyte laptop or the equivalent of storing…
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Investigators from the Frederick National Laboratory for Cancer Research will share their latest work regarding the use of pre-clinical models for compound screening and tumor characterization, bioinformatics and technology initiatives, among other topics, at the American Association for Cancer Research 2022 Annual Meeting. More than 30…
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The classical RAS family of proteins functions as molecular switches at the cell’s plasma membrane where it cycles between an active and inactive state. The active state initiates a cascade of events that promote downstream signaling to regulate cellular functions, such as cell proliferation. Mutations and dysregulation of the RAS-RAF-MEK-ERK…