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Cancer Research

The initial response to the COVID-19 pandemic disrupted cancer screenings as it caused many countries to suspend services following government guidance and to reallocate screening resources, a new study shows. “The full impact of the suspension of the screening and what this dynamic is going to mean in cancer in general is still to be seen,”…
Cleanup workers and others exposed to radiation from the Chernobyl nuclear accident in 1986 are unlikely to pass any genetic damage on to future generations, according to a new study. “This is good news for the people of Eastern Europe,” said Frederick National Laboratory scientist Meredith Yeager, first author on the multi-institutional study…
The Frederick National Laboratory for Cancer Research and biotech company Progenra, Inc., recently signed a contractor Cooperative Research and Development Agreement (cCRADA) to develop a novel therapy that could be capable of degrading KRAS. The human KRAS gene is one of the most elusive and potentially promising cancer therapy targets.…
The Computational Structural Biology Section draws on multidisciplinary advances to decipher the mechanisms and pharmacology of oncogenic proteins and their signaling at the detailed molecular level.   Our work is based on the concept of the free energy landscape. The landscape describes protein molecules as consisting of ensembles of…
The Flow Cytometry Support Laboratory is a clinical laboratory that provides state-of-the-art diagnostic clinical flow cytometric testing and immunophenotyping.  We support the National Cancer Institute Flow Cytometry Laboratory in the Laboratory of Pathology. The majority of flow cytometric testing we perform involves detecting minimal residual…
The Clinical Support Laboratory provides clinical trial processing support to the National Cancer Institute and performs sample testing with an emphasis on immune function.  We work with National Cancer Institute investigators on immune status of clinical trial subjects treated with anti-cancer immune modulators.    The laboratory provides…
Overview The NCI Mouse Repository is a resource for mouse cancer models and associated strains. This repository is funded by the National Cancer Institute and managed by Frederick National Laboratory. The repository makes strains available to all members of the scientific community. These strains are cryoarchived and distributed as frozen…
The AIDS and Cancer Virus Program works to improve the prevention, diagnosis, and treatment of HIV infection and AIDS-related tumors through basic, applied, and translational research, including development and sharing of novel experimental models, reagents and analytical methods.  Through investigator-driven research and extensive collaborations…
Image The National Cryo-Electron Microscopy Facility provides cancer researchers access to the latest technology for high-resolution imaging.  Our user facility addresses pressing national and regional needs for structural biologists to have access to advanced microscopes capable of supporting high-resolution…
The Nanotechnology Characterization Laboratory provides comprehensive preclinical characterization of nanomedicine formulations, encompassing physicochemical characterization as well as in vitro and in vivo immunology, pharmacology and toxicology evaluation. The laboratory has characterized hundreds of unique nanomedicine formulations and has…