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Cancer Research

HIV plays a direct role in causing blood cell cancers in rare instances, says a new study of HIV and tumor DNA. Scientists have long known that HIV contributes to several cancers by weakening the immune system’s ability to fend off cancer-causing infections like Kaposi sarcoma–associated herpesvirus and Epstein-Barr virus. However, this latest…
The Protein Expression Laboratory generates DNA, cell line, and protein reagents for biomedical research from basic science to drug discovery. The team uses cutting-edge protein production technologies to generate proteins using bacteria, insect cells, or mammalian cells at scales from micrograms to grams. Quality control is a major emphasis of…
A team of scientists has gone fishing, but they’re interested in more than the bounty of the seas: They’ve also cast out nets on land. And they’ve never left the laboratory. Their “nets” are high-powered chemical and biological analyses. The team, a group of cancer biologists, dermatologists, biochemists, natural product chemists, and…
A grim statistic is driving Steven Rosenberg’s mission to find new cancer treatments—and his partnership with Frederick National Laboratory (FNL) to do so. “Every year in the United States, about 600,000 people die of cancer, 90% of whom die of the solid epithelial cancers,” said Rosenberg, the M.D., Ph.D., chief of the National Cancer…
The Frederick National Laboratory for Cancer Research (FNL) not only tackles some of the world’s greatest biomedical challenges but also serves as a shared national resource to enable high-quality research beyond its walls. One way FNL does this is through the Technical Services Program. The Technical Services Program gives investigators…
Their study started to unravel the riddle of how cancers spread, demonstrating that tumors are comprised of different types of cells, or heterogeneous. Up to this point it was thought that cancer cells in a tumor were identical to each other. The work conducted by husband-and-wife Isaiah (Josh) Fidler, D.V.M., Ph.D., and Margaret Kripke, Ph.D…
Overview The Moonshot Pediatric Core at the Frederick National Laboratory provides resources and support to research teams within the Cancer Moonshot Initiative, helping them accelerate development of new novel immunotherapies and improving pediatric cancer treatments. The Moonshot Pediatric Core was established to support research teams…
Across the world, conferencing software flicked open on computer screens. It was 8 a.m. in San Francisco, 11 a.m. in Frederick, 5 p.m. in Madrid, 11 p.m. in Hong Kong. The first day of the Third National Cancer Institute RAS Initiative Symposium was about to begin. Time zones notwithstanding, scientists and onlookers were tuning in from offices,…
The initial response to the COVID-19 pandemic disrupted cancer screenings as it caused many countries to suspend services following government guidance and to reallocate screening resources, a new study shows. “The full impact of the suspension of the screening and what this dynamic is going to mean in cancer in general is still to be seen,”…
Cleanup workers and others exposed to radiation from the Chernobyl nuclear accident in 1986 are unlikely to pass any genetic damage on to future generations, according to a new study. “This is good news for the people of Eastern Europe,” said Frederick National Laboratory scientist Meredith Yeager, first author on the multi-institutional study…