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Research Technology

Image The Advanced Cryo-Electron Microscopy Technology Group explores emerging imaging platforms and develops methodologies, focusing on projects with the potential to make cryo-EM a more widely accessible technique.  The team focuses on single-particle analysis and cryo-electron tomography. Our group aims to…
The Retroviral Protein Chemistry Core provides preparative and analytic protein chemistry expertise for the characterization of retroviral virions and related samples. The core uses techniques that enable analyses with much smaller amounts of virus than was previously possible. 
Image The National Cryo-Electron Microscopy Facility provides cancer researchers access to the latest technology for high-resolution imaging.  Our user facility addresses pressing national and regional needs for structural biologists to have access to advanced microscopes capable of supporting high-resolution…
The Imaging Mass Cytometry Laboratory provides cancer researchers with high-dimensional imaging analysis of tumor tissue samples at subcellular resolution. We work with researchers interested in studying the tumor microenvironment, tumor-stromal cells interactions, and the roles of different subpopulations of immune cells in tumor progression and…
The Nanotechnology Characterization Laboratory provides comprehensive preclinical characterization of nanomedicine formulations, encompassing physicochemical characterization as well as in vitro and in vivo immunology, pharmacology and toxicology evaluation. The laboratory has characterized hundreds of unique nanomedicine formulations and has…
The Antibody Characterization Laboratory is a reference program that develops antibodies to be made available to the scientific community, including extensive antibody-characterization data and protocols. The laboratory uses an array of techniques to determine the properties of antibodies and other renewable reagents that can be used in cancer-…
The CLIA Molecular Diagnostics Laboratory makes clinical Sanger sequencing, genetic mutation detection, and gene expression technologies available to researchers.  We strive to support cancer and other disease-related research by providing access to cutting-edge technologies and specialized services, including nucleic acid extraction, fragment…
Researchers from the Sequencing Facility and Biomedical Informatics and Data Science Directorate at the Frederick National Laboratory (FNL) collaborated with the U.S. Food and Drug Administration (FDA) and other research centers across the U.S. to conduct a benchmark study establishing best practices for high-throughput single-cell RNA sequencing…
The Frederick National Laboratory (FNL) is providing scientists across the country with a key antigen used in antibody tests for the coronavirus after finding that the antigen is exceptionally sensitive and can be made rapidly and at low cost. This helps meet a pressing need for accurate testing. 3D model of SARS-CoV-2 created at the MRC…