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Research Technology

Computing collaboration makes massive microscopy analyses possible

News
On any given day, microscopist Susan Lea, D.Phil., and her team at NCI at Frederick collect more data than can fit on any standard hard drive, creating a challenge for data storage and analysis. Their average data collection is 5 terabytes, a quantity roughly 20 times the storage capacity of a 256-gigabyte laptop or the equivalent of storing…

STAR TREC takes on reproducibility, standardization, and better science

News
An initiative at Frederick National Laboratory for Cancer Research (FNL) is confronting what’s been dubbed the scientific “reproducibility crisis.” The effort, called STAR TREC (the Standards References and Training Research Committee), seeks to help the scientific community address reproducibility issues and aims to spur dialogue about better…

Three Frederick National Laboratory teams awarded 2021 NIH director’s awards

News
The National Institutes of Health (NIH) awarded three Frederick National Laboratory teams with NIH Director’s Awards for innovative approaches to COVID-19-related research that advances knowledge and enhances health. “It is a tremendous honor for three Frederick National Laboratory teams to be nominated by three distinct entities within NIH…

Scientists develop new concept for hard-to-treat cancers like mesothelioma

News
Think of a tumor and you might envision a disorganized mass. But tumors can also form a thin sheet over a surface. These can be hard to treat, especially when the surface has wrinkles and crevices. But there may be a new approach. Solid tumors can be successfully removed with surgery and residual cells destroyed. But cancers like the asbestos-…

Protein Expression Laboratory

Program
The Protein Expression Laboratory generates DNA, cell line, and protein reagents for biomedical research from basic science to drug discovery. The team uses cutting-edge protein production technologies to generate proteins using bacteria, insect cells, or mammalian cells at scales from micrograms to grams. Quality control is a major emphasis of…

Technical Service Program provides researchers worldwide with access to unique services

News
The Frederick National Laboratory for Cancer Research (FNL) not only tackles some of the world’s greatest biomedical challenges but also serves as a shared national resource to enable high-quality research beyond its walls. One way FNL does this is through the Technical Services Program. The Technical Services Program gives investigators…

Advanced Cryo-Electron Microscopy Technology Group

Program
Image The Advanced Cryo-Electron Microscopy Technology Group explores emerging imaging platforms and develops methodologies, focusing on projects with the potential to make cryo-EM a more widely accessible technique.  The team focuses on single-particle analysis and cryo-electron tomography. Our group aims to…

Retroviral Protein Chemistry Core

Program
The Retroviral Protein Chemistry Core provides preparative and analytic protein chemistry expertise for the characterization of retroviral virions and related samples. The core uses techniques that enable analyses with much smaller amounts of virus than was previously possible. 

National Cryo-Electron Microscopy Facility

Program
The National Cryo-Electron Microscopy Facility provides cancer researchers access to the latest technology for high-resolution imaging.  Image Image…

Imaging Mass Cytometry Laboratory

Program
The Imaging Mass Cytometry Laboratory provides cancer researchers with high-dimensional imaging analysis of tumor tissue samples at subcellular resolution. We work with researchers interested in studying the tumor microenvironment, tumor-stromal cells interactions, and the roles of different subpopulations of immune cells in tumor progression and…
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