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Genetics

Team connects genetic variant to poor outcomes after certain cancer treatment

News
Scientists have identified a genetic variant that can predict whether immunotherapy drugs called immune checkpoint inhibitors, used to treat cancer, might fail in certain patients. The team’s findings, which appear in Lancet Oncology, point to HLA-A*03, an allele (a form of a gene) found on chromosome 6 of human DNA. The presence of HLA-A*03 in…

Risk factor identified for disease disproportionately affecting African Americans

News
Frederick National Laboratory (FNL) scientists and their colleagues have identified a genetic risk factor for a dangerous blood pressure disorder in pregnant women of African descent, who are three times as likely to develop the disorder as White women. The scientists reported in the June issue of the American Journal of Kidney Diseases that…

Collaborative study puts Chernobyl hereditary mutation fears to rest

News
Cleanup workers and others exposed to radiation from the Chernobyl nuclear accident in 1986 are unlikely to pass any genetic damage on to future generations, according to a new study. “This is good news for the people of Eastern Europe,” said Frederick National Laboratory scientist Meredith Yeager, first author on the multi-institutional study…

Molecular Immunology Section

Program
The Molecular Immunology Section studies mechanisms of gene regulation, focusing on the innate immune system. The section is affiliated with, and provides expertise in gene regulation to the Laboratory of Cancer Immunometabolism of the National Cancer Institute Center for Cancer Research. 

Molecular Genetic Epidemiology Section

Program
Our laboratory focuses on the contribution of rare and common genetic variants to complex human disease such as HIV and HBV infection and outcomes, and to health disparities in African Americans, particularly the instance of chronic kidney disease.  

HLA Immunogenetics Section

Program
The HLA Immunogenetics section studies the influence of immunogenetic variation on risk of human disease, outcome to therapeutic treatment, and vaccination.  These studies include elucidation of the functional basis for the genetic associations identified.  The human leukocyte antigen (HLA) class I and class II genetic loci are the main subjects …

Epigenetics Section

Program
The Epigenetics Section studies mechanisms of chromatin remodeling, focusing on murine development. The section is affiliated with and provides expertise in chromatin biology to the Mouse Cancer Genetics Program of the National Cancer Institute Center for Cancer Research. 

Basic Science Program

Program
The Basic Science Program conducts independent research in basic and applied molecular biology, immunology, retrovirology, cancer biology, and human genetics.  Our goal is to understand biological processes related to cancer and other diseases and to develop cutting-edge tools to accelerate scientific progress.  The program’s areas of focus…

NCI Mouse Repository

Basic page
Overview The National Cancer Institute Mouse Repository is a resource for mouse cancer models, associated strains and mouse embryonic stem cells (mESCs) harboring inducible microRNA species supported by the Division of Cancer Biology and managed by the Frederick National Laboratory. Mouse models The repository distributes more than 150…

RAS Initiative

Basic page
Overview The National Cancer Institute RAS Initiative endeavors to better understand the RAS oncogene and discover its vulnerabilities to treat RAS-related cancers. About one-third of all human cancers are driven by mutations of the RAS family of genes. Though scientists have known about RAS for more than 30 years, a treatment to block…
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