Genetics

Scientists developed a bioinformatics pipeline to more accurately detect HIV drug resistance and potentially improve the quality of antiretroviral therapies for people living with HIV.

Scientists at the Frederick National Laboratory for Cancer Research (FNL) and their National Cancer Institute colleagues have developed a method that enhances the capacity to identify interactions between proteins and molecules that are critical to drug targeting. The study reported in Science Advances includes libraries to aid other researchers…

HLA class I heterozygote advantage is linked to beneficial outcomes after HIV infection.

Upon hearing earlier this year that she was elected to the prestigious American Academy of Arts and Sciences, cancer scientist Mary Carrington wished she could share the news with her beloved late father-in-law, a former law school dean at Duke. She had only discovered Paul Carrington’s academy membership after he died last year, when she and…

Five new projects led by Frederick National Laboratory for Cancer Research (FNL) scientists have earned Laboratory Directed Exploratory Research (LDER) funding for the upcoming fiscal year. The LDER program, which was modeled after the U.S. Department of Energy’s Laboratory Directed Research and Development program, provides FNL scientists…

Presence of HLA-A*03 appears to impede immune checkpoint inhibition therapy across tumor types.

Frederick National Laboratory (FNL) scientists and their colleagues have identified a genetic risk factor for a dangerous blood pressure disorder in pregnant women of African descent, who are three times as likely to develop the disorder as White women. The scientists reported in the June issue of the American Journal of Kidney Diseases that…

Cleanup workers and others exposed to radiation from the Chernobyl nuclear accident in 1986 are unlikely to pass any genetic damage on to future generations, according to a new study. “This is good news for the people of Eastern Europe,” said Frederick National Laboratory scientist Meredith Yeager, first author on the multi-institutional study…

Studies mechanisms of gene regulation, focusing on the innate immune system.