News
New peptide-based matrix redefines HLA heterozygosity, supporting its advantage in HIV disease
HLA class I heterozygote advantage is linked to beneficial outcomes after HIV infection, presumably through greater breadth of HIV epitope presentation and cytotoxic T cell response. Among heterozygotes, however, distinct allotype pairs differ in…
News
Upon hearing earlier this year that she was elected to the prestigious American Academy of Arts and Sciences, cancer scientist Mary Carrington wished she could share the news with her beloved late father-in-law, a former law school dean at Duke.
She had only discovered Paul Carrington’s academy membership after he died last year, when she and…
News
Five new projects led by Frederick National Laboratory for Cancer Research (FNL) scientists have earned Laboratory Directed Exploratory Research (LDER) funding for the upcoming fiscal year.
The LDER program, which was modeled after the U.S. Department of Energy’s Laboratory Directed Research and Development program, provides FNL scientists…
News
Scientists have identified a genetic variant that can predict whether immunotherapy drugs called immune checkpoint inhibitors, used to treat cancer, might fail in certain patients.
The team’s findings, which appear in Lancet Oncology, point to HLA-A*03, an allele (a form of a gene) found on chromosome 6 of human DNA. The presence of HLA-A*03 in…
News
Frederick National Laboratory (FNL) scientists and their colleagues have identified a genetic risk factor for a dangerous blood pressure disorder in pregnant women of African descent, who are three times as likely to develop the disorder as White women.
The scientists reported in the June issue of the American Journal of Kidney Diseases that…
News
Cleanup workers and others exposed to radiation from the Chernobyl nuclear accident in 1986 are unlikely to pass any genetic damage on to future generations, according to a new study.
“This is good news for the people of Eastern Europe,” said Frederick National Laboratory scientist Meredith Yeager, first author on the multi-institutional study…
Program
The Molecular Immunology Section studies mechanisms of gene regulation, focusing on the innate immune system.
The section is affiliated with and provides expertise in gene regulation to the Cancer Innovation Laboratory of the National Cancer Institute Center for Cancer Research.
The Molecular Immunology Section studies mechanisms of gene regulation, focusing on the innate immune system. The section is affiliated with, and provides expertise in gene regulation to the Laboratory of Cancer Immunometabolism of the National Cancer Institute Center for Cancer Research.
Program
Our laboratory focuses on the contribution of rare and common genetic variants to complex human disease such as HIV and HBV infection and outcomes, and to health disparities in African Americans, particularly the instance of chronic kidney disease.
Program
The HLA Immunogenetics Section aims to understand the genetic basis for how variation in the immune response across individuals confers resistance or susceptibility to human disease. Once a genetic association is identified, we aim to determine its functional basis.
The HLA Immunogenetics section studies the influence of immunogenetic variation on risk of human disease, outcome to therapeutic treatment, and vaccination. These studies include elucidation of the functional basis for the genetic associations identified.
The human leukocyte antigen (HLA) class I and class II genetic loci are the main subjects …
Program
The Epigenetics Section studies chromatin structure and function and how chromatin regulates DNA access and, thus, controls biological processes.
Our scientists focus on murine development, in particular how the chromatin remodeling protein LSH affects development. Our team is affiliated with and provides chromatin biology expertise to the…
The Epigenetics Section studies mechanisms of chromatin remodeling, focusing on murine development. The section is affiliated with and provides expertise in chromatin biology to the Mouse Cancer Genetics Program of the National Cancer Institute Center for Cancer Research.
