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Pathology

Nanotechnology enables potential novel imaging agent for early pancreatic cancer detection

News
Frederick National Laboratory (FNL) scientists, led by Stephan Stern, Ph.D., and their colleagues have created a novel imaging agent that, with further development, might detect deadly pancreatic cancer at its earliest, most-treatable stages and thereby improve the prognosis for patients. Pancreatic cancer has a high mortality rate because it…

Basic Science Program

Program
The Basic Science Program conducts independent research in basic and applied molecular biology, immunology, retrovirology, cancer biology, and human genetics.  Our goal is to understand biological processes related to cancer and other diseases and to develop cutting-edge tools to accelerate scientific progress.  The program’s areas of focus…

Laboratory of Human Retrovirology and Immunoinformatics

Program
The Laboratory of Human Retrovirology and Immunoinformatics performs basic, clinical, and bioinformatic research to gain a better understanding of the immunopathological effects of HIV and HIV-related infectious diseases and how they’re influenced by genetics. We support and collaborate with the National Institute of Allergy and Infectious…

Viral Oncology Section

Program
The Viral Oncology Section studies the role of viruses in cancer, focusing primarily on Kaposi’s sarcoma–associated herpesvirus (KSHV) and related malignancies. Our research encompasses epidemiology, molecular virology, immunology, and translational studies. 

Tissue Analysis Core

Program
The Tissue Analysis Core provides state-of-the-art tissue analysis capabilities including immunofluorescence, single and double label immunohistochemistry, in situ hybridization, quantitative image analysis, and laser capture microdissection. The core supports investigators within the AIDS and Cancer Virus Program and both intramural and…

Retroviral Pathogenesis Section

Program
The Retroviral Pathogenesis Section conducts both in vitro and in vivo research to improve the basic understanding of AIDS virus pathogenesis through applied and basic studies. Applied studies evaluate candidate vaccines and other prevention approaches, along with studies of novel drug and immunotherapeutic interventions to target virus that…

Laboratory Animal Sciences Program

Program
The Laboratory Animal Sciences Program is a comprehensive resource for scientists performing animal-based research to better understand cancer, HIV/AIDS, and other infectious diseases. We provide veterinary care, regulatory support, and routine and specialized husbandry services. Image…

FNL team raises awareness of mouse kidney virus affecting research reproducibility

News
Kidney disease researchers should be on the lookout for a newly described mouse virus that appears to be relatively common and could affect the reproducibility of research involving mice that are infected but show no symptoms, according to a new study. “Turns out, this virus is common in wild mice and research colonies around the world and…
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