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HIV/AIDS Research

HIV plays a direct role in causing blood cell cancers in rare instances, says a new study of HIV and tumor DNA. Scientists have long known that HIV contributes to several cancers by weakening the immune system’s ability to fend off cancer-causing infections like Kaposi sarcoma–associated herpesvirus and Epstein-Barr virus. However, this latest…
The Frederick National Laboratory for Cancer Research (FNL) not only tackles some of the world’s greatest biomedical challenges but also serves as a shared national resource to enable high-quality research beyond its walls. One way FNL does this is through the Technical Services Program. The Technical Services Program gives investigators…
The Basic Science Program conducts independent research in basic and applied molecular biology, immunology, retrovirology, cancer biology, and human genetics.  Our goal is to understand biological processes related to cancer and other diseases and to develop cutting-edge tools to accelerate scientific progress.  The program’s areas of focus…
The Radiochemistry Support Group develops radiochemical methods to produce radiotracers for in vivo imaging in HIV studies, and chemical and biochemical methods to synthesize, identify, and characterize the radiolabeled antibody, cytokine, and small molecular probes.  We develop radiotracers to support noninvasive, in-vivo whole-body imaging in…
The Laboratory of Molecular Cell Biology conducts research in collaboration with scientists at the National Institute of Allergy and Infectious Diseases to understand the biology of T cell activation and HIV persistence.  We support the Laboratory of Immunoregulation by developing and performing quantitative and qualitative polymerase chain…
The Laboratory of Human Retrovirology and Immunoinformatics performs basic, clinical, and bioinformatic research to gain a better understanding of the immunopathological effects of HIV and HIV-related infectious diseases and how they’re influenced by genetics. We support and collaborate with the National Institute of Allergy and Infectious…
The Blood Processing Core monitors viral load in patients with HIV and performs sequential studies using samples obtained from patients with cancer, AIDS, chronic granulomatous disease, or other diseases associated with immunologic dysfunction.  The core collects clinical specimens from inpatient units and clinics within the National Institutes…
The AIDS Monitoring Laboratory provides clinical trial support by performing sequential studies of immune function in individuals with HIV or other emerging or re-emerging infectious diseases throughout the patient’s treatment.  Our work helps assess the efficacy and mode of action of investigational treatment agents and guides determination of …
The Viral Persistence Section studies the establishment, spread, and maintenance of persistent AIDS virus infections and persistent opportunistic viral infections that cause cancer in the setting of AIDS.  The laboratory uses a combination of nonhuman primate models of HIV infection, along with advanced cell culture, virology, and molecular…
The Viral Oncology Section studies the role of viruses in cancer, focusing primarily on Kaposi’s sarcoma–associated herpesvirus (KSHV) and related malignancies. Our research encompasses epidemiology, molecular virology, immunology, and translational studies.