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Virology

Retrovirus-Cell Interaction Section

Program
The Retrovirus-Cell Interaction Section uses in vitro and in vivo approaches to define both the potential and the limitations of cellular immune control of AIDS virus infection. We focus on studies in nonhuman primate (NHP) models, using lymphocyte engineering approaches to study and optimize the ability of cellular immune responses to…
The Retrovirus-Cell Interaction Section uses both in vitro and in vivo studies to define the characteristics and potential of cellular immune control of AIDS virus infection. Our researchers study the interactions between AIDS viruses and their host cells, focusing on SIV and rhesus macaque T cell…

Retroviral Pathogenesis Section

Program
The Retroviral Pathogenesis Section conducts basic, applied, and translational research to understand retroviral disease mechanisms. We work with nonhuman primate (NHP) models, employing in vitro and in vivo approaches, and evaluate strategies to more effectively prevent and treat AIDS virus infections and their consequences. Our basic studies…
The Retroviral Pathogenesis Section conducts both in vitro and in vivo research to improve the basic understanding of AIDS virus pathogenesis through applied and basic studies. Applied studies evaluate candidate vaccines and other prevention approaches, along with studies of novel drug and…

Retroviral Evolution Section

Program
We use molecular biology approaches to develop and employ novel viral systems to leverage the advantages of nonhuman primate models. Our work addresses critical questions in key areas of AIDS research, including transmission, adaptation, persistence, and evolution that allows the pathogen to evade eradication/cure strategies. Arresting the HIV…
The Retroviral Evolution Section conducts groundbreaking research to better understand fundamental features of HIV transmission, persistence, and evolution that allow the pathogen to continue evading eradication strategies. Our scientists harness molecular biology approaches to generate, manipulate, and employ novel viral…

Quantitative Molecular Diagnostics Core

Program
The Quantitative Molecular Diagnostics Core develops and applies assays to measure levels of AIDS virus nucleic acids and related analytes in specimens from nonhuman primate (NHP) studies. We provide quantitative molecular analyses for laboratories within the AIDS and Cancer Virus Program, the National Institutes of Health, and the extramural…
The Quantitative Molecular Diagnostics Core provides quantitative molecular analyses for laboratories within the AIDS and Cancer Virus Program, National Institutes of Health, and external research community.The core performs testing for SIV and related viruses, with a focus on …

AIDS and Cancer Virus Program

Program
The AIDS and Cancer Virus Program investigates ways to diagnose, prevent, and treat HIV infection and AIDS-related tumors associated with cancer viruses, such as Kaposi sarcoma–associated herpesvirus. We have principal investigator-headed research sections and research support cores that provide innovative, often unique, capabilities in support of…
The AIDS and Cancer Virus Program works to improve the prevention, diagnosis, and treatment of HIV infection and AIDS-related tumors through basic, applied, and translational research, including development and sharing of novel experimental models, reagents and analytical methods. Through investigator-…

AIDS research team aims to push boundaries in science and beyond

News
Researchers are launching a new project aimed at understanding vaginal transmission of HIV and examining what happens in the earliest stages of infection in people with a cervix, who represent about one-fifth of new cases each year. Christine Fennessey, Ph.D. and Claire Deleage, Ph.D. in the Frederick National Laboratory’s AIDS and Cancer…
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