The Viral Persistence Section studies the establishment, spread, and maintenance of persistent AIDS virus infections and persistent opportunistic viral infections that cause cancer in the setting of AIDS.
The laboratory uses a combination of nonhuman primate models of HIV infection, along with advanced cell culture, virology, and molecular…
The Viral Oncology Section studies the role of viruses in cancer, focusing primarily on Kaposi’s sarcoma–associated herpesvirus (KSHV) and related malignancies. Our research encompasses epidemiology, molecular virology, immunology, and translational studies.
The Viral Evolution Core provides expertise in specialized sequencing techniques, molecular cloning, and viral evolution analyses. The core primarily generates viral genome sequencing data and analysis. Our scientists support the AIDS and Cancer Virus Program, National Cancer Institute, National Institutes of Health, and the broader AIDS research…
and potential of cellular immune control of AIDS virus infection focusing on SIV infection of rhesus macaques as a model system. Approaches employed include molecular engineering of T cells for expression of antiviral T cell receptors and functional activities, along with receptors to direct trafficking of infused cells to relevant tissues in…
The Retroviral Protein Chemistry Core provides preparative and analytic protein chemistry expertise for the characterization of retroviral virions and related samples. The core uses techniques that enable analyses with much smaller amounts of virus than was previously possible.
The Retroviral Pathogenesis Section conducts both in vitro and in vivo research to improve the basic understanding of AIDS virus pathogenesis through applied and basic studies. Applied studies evaluate candidate vaccines and other prevention approaches, along with studies of novel drug and immunotherapeutic interventions to target virus that…
The Retroviral Evolution Section conducts groundbreaking research to better understand fundamental features of HIV transmission, persistence, and evolution that allow the pathogen to continue evading eradication strategies.
Our scientists harness molecular biology approaches to generate, manipulate, and employ novel viral systems to take full…
The Quantitative Molecular Diagnostics Core provides quantitative molecular analyses for laboratories within the AIDS and Cancer Virus Program, National Institutes of Health, and external research community.
The core performs testing for SIV and related viruses, with a focus on determining viral RNA and viral DNA levels in specimens derived from…
The AIDS and Cancer Virus Program works to improve the prevention, diagnosis, and treatment of HIV infection and AIDS-related tumors through basic, applied, and translational research, including development and sharing of novel experimental models, reagents and analytical methods.
Through investigator-driven research and extensive collaborations…
Researchers are launching a new project aimed at understanding vaginal transmission of HIV and examining what happens in the earliest stages of infection in people with a cervix, who represent about one-fifth of new cases each year.
Christine Fennessey, Ph.D. and Claire Deleage, Ph.D. in the Frederick National Laboratory’s AIDS and Cancer…
