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Virology

Graphic representation of COVID-19 pandemic response workflow

From HPV to COVID-19 and beyond: Leveraging the power of serology and standards

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FNL’s rapid COVID response is a model to address future pandemics.
Illustration of COVID-19 virus

Investigating the Immune Response to SARS-CoV-2

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A new test detects exposure to viruses that cause COVID-19 and their relatives. Research using it could aid efforts to protect against infections.    A team at the Frederick National Laboratory for Cancer Research developed a test capable of assessing exposure to the virus that causes COVID-19 and to a selection of its variants and viral…
Computer rendering of influenza virus

Nanoparticle-based flu vaccine performs well in early phase clinical trial

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A nanoparticle-based flu vaccine discovered and developed by the Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), was manufactured by Frederick National Laboratory (FNL) for a Vaccine Research Center Phase 1 clinical trial. The vaccine was found to be safe, well-tolerated, and immunogenic against multiple flu…
medical professional adminstering a vaccine

Lack of reaction to the COVID-19 shot doesn’t mean it’s not working

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Results showed no correlation between severity of symptoms and levels of antibodies.
Scientist holds pipette at workbench

Three Frederick National Laboratory teams awarded 2021 NIH director’s awards

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The National Institutes of Health (NIH) awarded three Frederick National Laboratory teams with NIH Director’s Awards for innovative approaches to COVID-19-related research that advances knowledge and enhances health. “It is a tremendous honor for three Frederick National Laboratory teams to be nominated by three distinct entities within NIH…
A map of the U.S. showing regions and seroprevalence percentage

Collaborative seroprevalence study highlights Protein Expression Laboratory’s capabilities

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In a recent study that sought to measure antibody prevalence in participants who had not previously been diagnosed with a SARS-CoV-2 infection, a team of National Institutes of Health researchers reported that for every person diagnosed with COVID-19 in the spring and summer of 2020, it’s estimated that five additional people infected with the…
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AIDS research team aims to push boundaries in science and beyond

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Researchers are launching a new project aimed at understanding vaginal transmission of HIV and examining what happens in the earliest stages of infection in people with a cervix, who represent about one-fifth of new cases each year. Christine Fennessey, Ph.D. and Claire Deleage, Ph.D. in the Frederick National Laboratory’s AIDS and Cancer…
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HPV Serology Laboratory

Program
Leads development, validation, and standardization of serology assays as well as high throughput testing for HPV.
Image The COVID-19 Serology Laboratory establishes standards and coordinates research for the National Cancer Institute Serological Sciences Network (SeroNet).  At the start of the COVID-19 pandemic in March, 2020, our scientists pivoted to evaluate the performance of SARS-CoV-2 antibody…

Viral Persistence Section

Program
NHP models to investigate mechanism of persistent AIDS virus infections.
The Viral Persistence Section studies the establishment, spread, and maintenance of persistent AIDS virus infections and persistent opportunistic viral infections that cause cancer in the setting of AIDS. The laboratory uses a combination of nonhuman primate models of HIV infection, along with advanced cell culture,…

Viral Oncology Section

Program
Epidemiology, immune response, and genetics of Kaposi sarcoma-associated herpesvirus.
The Viral Oncology Section studies the role of viruses in cancer, focusing primarily on Kaposi’s sarcoma–associated herpesvirus (KSHV) and related malignancies. Our research encompasses epidemiology, molecular virology, immunology, and translational studies. 
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