Available Strain Details

Strain Information
Strain Number: 01XMB Register Interest
Common Strain Name: Mdm2-Y393F
Strain Nomenclature: B6;129S4-Mdm2tm4.1Snj/Nci
Animal State:
Release Category (Required for MTA form): B3,C1


Strain Description: These mice bear a point mutation in Mdm2 at the cAbl phosphorylation site. These mice display no defects in p53 stabilization, yet have increased spontaneous and oncogene induced tumors, and reduced sensitivity to lethal radiation.
Mutation Information
Mutation Type: Targeted Null
Gene Name: Murine double minute 2
Gene Symbol: Mdm2
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6;129S4
Approx. Generation:
Organ Site:
Additional Information
Husbandry: C57BL/6NCr females x heterozygous males. When maintained as a live colony, the average litter size is 7-8.
Genotyping Information:
Donating Investigator: Dr. Stephen Jones

Key Reference: Carr et al. Proc. Natl. Acad. Sci. USA. 113:52, 15024-15029. PMID: 27956626, MGI: 5897766 [Pubmed Abstract]

Related Reference: Carr, M.I., and Jones, S.N. Trans. Cancer Res. 5(6):707-724. PMID 28690977 [Pubmed Abstract]

Sponsor: NIH CA77735