Available Strain Details

Strain Information
Common Strain Name: Mdm2 transgenic Pricing and Ordering Information
Strain Nomenclature: B6.129S7-Tg(Mdm2)1Snj/Nci
Animal State: Cryoarchived Strains
Release Category (Required for MTA form): B3,C1


Strain Description: The mice overexpress Mdm2 in most tissues (3-5 fold endogenous levels), develop spontaneous cancers, and show reduced levels of p53 activity in a variety of tissues. These mice are the only Mdm2 transgenic model available.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: Murine double minute 2
Transgene Symbol: Mdm2
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6.129S7
Approx. Generation:
Organ Site:
Additional Information
Cryopreservation Mating Scheme: The cryopreservaiton mating scheme is wildtype females x heterozygous males
Genotyping Information: Protocol 1: Allele: Tg(Mdm2)1Snj/Nci
Donating Investigator: Dr. Stephen Jones

Key Reference: Jones, S.N. et al. Proc. Natl. Acad. Sci. USA. 95:15608-15612, PMID 9861017, J: 51661 [Pubmed Abstract]

Related Reference: Steinman, H.A. et al. Oncogene 24:7935-7940, PMID 16027727 [Pubmed Abstract]

Sponsor: NIH CA77735