Available Strain Details

Strain Information
Common Strain Name: iMycEu Pricing and Ordering Information
Strain Nomenclature: STOCK Ightm1Janz/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B1,D

Strain Description: Mouse c-Myc was inserted into the mouse immunoglobulin heavy-chain locus, Igh, just 5' of the intronic enhancer, Eµ, to mimic the MYC-activating chromosomal t(8;14)(q24;q32) translocation most commonly observed in human endemic Burkitt lymphoma. Heterozygous iMyc mice develop a spectrum of B-cell tumors, including Burkitt-like lymphoblastic B-cell lymphoma, diffuse large B-cell lymphoma, and plasmacytoma.
Mutation Information
Mutation Type: Targeted
Gene Name: Immunoglobulin heavy chain complex - Myelocytomatosis oncogene (inserted)
Gene Symbol: Igh-Myc
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: STOCK
Approx. Generation: 14
Organ Site: Hematopoetic
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is C57BL/6 females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as heterozygotes. NOTE: Homozygous mice are immunodeficient due to the absence of mature B-cells and susceptible to opportunistic infections.
Genotyping Information: Protocol 1: Allele: Igh<tm1(Myc)Janz>
Donating Investigator: Dr. Siegfried Janz

Key Reference: Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. Park SS, Kim JS, Tessarollo L, Owens JD, Peng L, Han SS, Tae Chung S, Torrey TA, Cheung WC, Polakiewicz RD, McNeil N, Ried T, Mushinski JF, Morse HC 3rd, Janz S. Cancer Res. 2005 Feb 15;65(4):1306-15. PMID 15735016 [Pubmed Abstract]