Available Strain Details

Strain Information
Common Strain Name: MMTV/c-myc Pricing and Ordering Information
Strain Nomenclature: FVB-Tg(MMTV-Myc)141-3Led/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B5,D

Strain Description: Develop adenocarcinomas of mammary tissue and in some cases lymphomas develop at low frequency.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: Myelocytomatosis oncogene (human)
Transgene Symbol: MYC
Promotor Name: Mouse mammary tumor virus
Promotor Symbol: MMTV
Current Genetic Background: FVB/N
Approx. Generation: 42
Organ Site: Breast
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is FVB/N females x hemizygous males. When maintained as a live colony, breeder pairs were distributed as a hemizygote (male or female) x wildtype FVB/N (male or female).
Genotyping Information: Protocol 1: Allele: Tg(MMTV-Myc)3Led
Donating Investigator: Dr. Philip Leder

Key Reference: Sinn E, Muller W, Pattengale P, Tepler I, Wallace R, Leder P. 1987. Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell 49:465-75 PMID: 3032456 [Pubmed Abstract]