Available Strain Details

Strain Information
Common Strain Name: P190 BCR-ABL Pricing and Ordering Information
Strain Nomenclature: B6;CBA-Tg(BCR/ABL)623Hkp/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B1,D

Strain Description: Mice develop leukemia/lymphoma generally within one year of age. This serves as a model for Philadelphia-chromosome (Ph-chromosome) positive leukemia. It closely models Ph-positive acute lymphoblastic leukemia in humans. The model can be used to test possible therapeutics (see reference 2) as well as studying disease progression.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: BCR/ABL Fusion Protein (Human)
Transgene Symbol: BCR/ABL
Promotor Name: Metallothionine 1
Promotor Symbol: Mt1
Current Genetic Background: B6;CBA
Approx. Generation:
Organ Site: Hematopoietic
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is B6CBAF1/Cr females x homozygous males or B6CBAF1/Cr females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as homozygotes.
Genotyping Information: Protocol 1: Allele: Tg(BCR-ABL)623Hkp
Donating Investigator: Dr. Nora Heisterkamp

Key Reference: Voncken JW, Griffiths S, Greaves MF, Pattengale PK, Heisterkamp N, Groffen J. Restricted oncogenicity of BCR/ABL p190 in transgenic mice. 1992 Cancer Res. 52:4534-9. PMID: 1643646 [Pubmed Abstract]

Related Reference: Reichert A, Heisterkamp N, Daley GQ, Groffen J. Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336. 2001 Blood. 97:139 PMID: 11222386 [Pubmed Abstract]