Available Strain Details

Strain Information
Common Strain Name: CAGs-rtTA Pricing and Ordering Information
Strain Nomenclature: B6N.FVB(Cg)-Tg(CAG-rtTA3)4288Slowe/Nci
Animal State: Cryoarchived Strains
Release Category (Required for MTA form): B1


Strain Description: When combined with a tetO/TRE transgene, this CAG-rtTA mutation enables conditional expression in the presence of doxycycline. This CAGs-rtTA3 transgenic strain is a component of a novel system applying conditional RNA interference (RNAi) to knock out targeted genes.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: reverse tetracycline-controlled transactivator, E. coli
Transgene Symbol: rtTA3
Promotor Name: cytomegalovirus (CMV) early enhancer element and chicken beta-actin
Promotor Symbol: CAGS
Current Genetic Background: B6N.FVB(Cg)
Approx. Generation:
Organ Site:
Additional Information
Cryopreservation Mating Scheme:
Genotyping Information:
Donating Investigator: Dr. Scott Lowe

Key Reference: Premsrirut PK; Dow LE; Kim SY; Camiolo M; Malone CD; Miething C; Scuoppo C; Zuber J; Dickins RA; Kogan SC; Shroyer KR; Sordella R; Hannon GJ; Lowe SW. 2011. A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell 145(1):145-58. [PubMed: 21458673] [MGI Ref ID J:171191] PMID: 21458673 [Pubmed Abstract]