Available Strain Details

Strain Information
Common Strain Name: Msh6 null Pricing and Ordering Information
Strain Nomenclature: B6.129-Msh6tm1Rak/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B

Strain Description: This strain carries a null mutation in the DNA mismatch repair gene Msh6. Cells from mice homozygous for this mutation are incapable of repairing single-nucleotide but are capable of repairing insertion/deletion mismatches. Homozygous mice die between 3 and 15 months of age as a result of various tumors, including those of the GI tract.
Mutation Information
Mutation Type: Targeted
Gene Name: MutS homolog 6
Gene Symbol: Msh6
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6.129
Approx. Generation: N11
Organ Site: GI
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is C57BL/6 females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as a heterozygote (male or female) x wildtype C57BL/6 (male or female).
Genotyping Information: Protocol 1: Allele: Msh6<tm1Rak>
Donating Investigator: Dr. Raju Kucherlapati

Key Reference: Edelmann W, Yang K, Umar A, Heyer J, Lau K, Fan K, Liedtke W, Cohen PE, Kane MF, Lipford JR, Yu N, Crouse GF, Pollard JW, Kunkel T, Lipkin M, Kolodner R, Kucherlapati R. Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. 1997. Cell. 91, 467-477 PMID: 9390556 [Pubmed Abstract]