Available Strain Details

Strain Information
Common Strain Name: CAG-LSL-EGFRvIII Pricing and Ordering Information
Strain Nomenclature: STOCK Col1a1tm2(CAG-EGFR*)Char/Nci
Animal State: Cryoarchived Strains
Release Category (Required for MTA form): B3,D


Strain Description: None until presented to tissue specific Cre recombinase.
Mutation Information
Mutation Type: Targeted
Gene Name: 5'-mutant epidermal growth factor receptor
Gene Symbol: EGFRvIII
Transgene Name:
Transgene Symbol:
Promotor Name: CAGGS, chicken and viral
Promotor Symbol: CAGGS
Current Genetic Background: STOCK
Approx. Generation: 7
Organ Site: Any
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is FVB females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as a heterozygote (male or female) x wildtype FVB (male or female). Average litter size is 7.
Genotyping Information: Protocol 1: Allele: Col1a1<tm2(CAG-EGRF*)Char>
Donating Investigator: Dr. Alain Charest

Key Reference: Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2712-6. doi: 10.1073/pnas.0813314106. Epub 2009 Feb 5., Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis, Zhu H1, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Pfannl R, Bronson RT, Chen JW, Weissleder R, Housman DE, Charest A., PMID: 19196966 [PubMed - indexed for MEDLINE]PMCID: PMC2650331 [Pubmed Abstract]

Sponsor: National Institutes of Health U54 CA119349, U01 CA141556