Available Strain Details

Strain Information
Common Strain Name: miR-10b KO Pricing and Ordering Information
Strain Nomenclature: C57BL/6-Mir10btm1.2Arte/Nci
Animal State: Cryoarchived Strains
Release Category (Required for MTA form): B3,C1

Strain Description: miR-10b is largely dispensable for normal development but critical to tumorigenesis. Loss of miR-10b delays oncogene-induced mammary tumorigenesis and suppresses epithelial?mesenchymal transition, intravasation, and metastasis in a mouse model of metastatic breast cancer (MMTV-PyMT transgenic).
Mutation Information
Mutation Type:
Gene Name: microRNA 10b
Gene Symbol: miR-10b
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: C57BL/6
Approx. Generation:
Organ Site: Whole body
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is C57BL/6 females x heterozygous males.
Genotyping Information: Protocol 1: Allele: Mir10b<tm1.2Arte>
Donating Investigator: Dr. Li Ma

Key Reference: Cancer Res. 2016 Nov 1;76(21):6424-6435. PMID: 27569213 [Pubmed Abstract]