The Basic Science Program (BSP) pursues independent, multidisciplinary research programs in basic and applied molecular biology, immunology, retrovirology, cancer biology, and human genetics. Research efforts and support are an integral part of the Center for Cancer Research at the Frederick National Laboratory for Cancer Research.
The goal of BSP is to gain new knowledge and understanding of biological processes relevant to cancer and other diseases, and to develop cutting-edge tools to accelerate progress. Areas of focus include cancer, retrovirology, basic biology, structural biology, informatics, cellular mechanisms, and the genetic factors that influence disease susceptibility and progression.
- Sequence and Phylogenetic Analysis of the Untranslated Promoter Regions for HLA Class I Genes
- 17β-Hydroxywithanolides as Sensitizers of Renal Carcinoma Cells to Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) Mediated Apoptosis: Structure-Activity Relationships
- TET2 binds the androgen receptor and loss is associated with prostate cancer
- Release of Cytochrome C from Bax Pores at the Mitochondrial Membrane
- APOL1 Risk Variants and Cardiovascular Disease: Results From the AASK (African American Study of Kidney Disease and Hypertension)
- Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature
- Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells
Program Areas and Laboratories
- Human Leukocyte Antigens (HLA) Immunogenetics
- Molecular Immunology
- Molecular Immunotherapy
- Hematopoiesis and Stem Cell Biology
- Computational Structural Biology
- Molecular Genetic Epidemiology