Viral Persistence Section (VPS)
There are a number of transmissible human viral infections that, once established, persist in the host indefinitely. HIV-1 establishes disseminated sources of replication-competent virus that persist for the lifetime of the infected individual, even in the presence of effective, long-term antiretroviral therapy. Intriguingly, concomitant HIV-1 infection can also increase the pathogenic potential of other persistent viral infections, such as gammaherpesviruses. The Viral Persistence Section (VPS) utilizes in vivo nonhuman primate models of HIV infection, along with in vitro and ex vivo cell culture, virology, and molecular biology techniques to study the establishment, spread, and maintenance of persistent AIDS virus infections and to evaluate novel treatment approaches to reduce persistent viral reservoirs. In addition to utilizing existing models and approaches, we seek to develop novel animal models and in vitro and ex vivo assays to better understand persistent virus sources. We also are actively developing novel assays and experimental approaches to better study gammaherpesvirus-associated, AIDS-related malignancies that develop in SIV/SHIV infected macaques, with the ultimate goal of developing and applying a tractable nonhuman primate model for these opportunistic, persistent infections.
Viral Persistence Section Staff
Gregory Q. Del Prete, Ph.D.
- Nag, Mukta
- McNickle, Timothy